ch.19

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Author:
cellbio
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72662
Filename:
ch.19
Updated:
2011-03-13 21:00:14
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cell bio
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cell bio ch 19
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  1. What does DNA Polymerase I do & what type of cell is it found in?
    • DNA synthesis; 3' to 5' exonuclease (for proofreading); 5' to 3' exonuclease; removes and replaces RNA primers used in DNA replication (also functions in excision repair of damaged DNA).
    • Bacteria Cells
  2. What does DNA Polymerase III do & what type of cell is it found in?
    • DNA synthesis; 3' to 5' exonuclease (for proofreading); used in synthesis of both DNA strands
    • Bacteria Cells
  3. What does DNA Polymerase alpha do & what type of cell is it found in?
    • Nuclear DNA synthesis; forms complex with primase and begins DNA synthesis at the 3' end of RNA primers for both leading and lagging strands (also functions in DNA repair).
    • Eukaryotes
  4. What does DNA Polymerase gamma do & what type of cell is it found in?
    • Mitochondrial DNA synthesis
    • Eukaryotes
  5. What does DNA Polymerase delta do & what type of cell is it found in?
    • Nuclear DNA synthesis; 3' to 5' exonuclease (for proofreading); involved in lagging and leading strand synthesis (also functions in DNA repair). They think DNA Pol epsilon does the same thing.
    • Eukaryotes
  6. What does Primase do & what type of cell is it found in?
    • RNA synthesis; makes RNA oligonucleotides that are used as primers for DNA synthesis
    • Both Eukaryotes and Bacteria
  7. What does DNA helicase do & what type of cell is it found in?
    • Unwinds double-stranded DNA
    • Both Eukaryotes and Bacteria
  8. What does Single-stranded DNA binding protein (SSB) do & what type of cell is it found in?
    • Binds to single-stranded DNA; stabilizes strands of unwound DNA in an extended configuration that facilitates access by other proteins.
    • Both Eukaryotes and Bacteria
  9. What does DNA ligase do & what type of cell is it found in?
    • Makes covalent bonds to join together adjacent DNA strands, including the okazaki fragments in lagging strand DNA synthesis and the new and old DNA segments in excision repair of DNA.
    • Both Eukaryotes and Bacteria
  10. What does an initiator proteinn do & what type of cell is it found in?
    • Bind to origin of replication and initiate unwinding of DNA double helix
    • Both Eukaryotes and Bacteria
  11. What does telomerase do & what type of cell is it found in?
    • Using an integral RNA molecule as template, synthesizes DNA for extension of telomeres (repetitive sequence at the ends of chromosomal DNA)
    • Eukaryotes
  12. What three things are required for DNA replication to occur?
    • 1. DNA Polymerase
    • 2. Primers
    • 3. Nucleotides
  13. What is an exonuclease?
    Enzymes that degrade nucleic acids (usually DNA) from one end. Unlike endonucleases that make internal cuts.

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