Antibiotic notes

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Author:
pdnguyen
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72775
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Antibiotic notes
Updated:
2011-03-14 01:56:04
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antibiotic notes
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Antibiotic notes
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  1. 1st Generation penicillin
    • Gram positive
    • Penicillin G, Pencillin V, Nafcillin, Isoxazolyl penicillins
  2. 2nd Generation penicillin
    • Gram negative
    • Aminopenicillins
  3. 3rd Generation penicillin
    • Pseudomonas
    • Carbenicillin
  4. 4th Generation penicillin
    • More potent
    • Ureidopenicillins
    • Piperacillin
  5. Dicloxacillin
    Beta-lactamase inhibitor
  6. Oxacillin
    Hepatitis with prolonged use
  7. Ampicllin
    R=H
  8. Amoxicillin
    R=OH
  9. Beta-lactamase inhibitors
    • Combined with aminopenicillin
    • Against plasmid-mediated
  10. Clavulanic acid
    Suicide substrate
  11. Ticarcillin
    • Combined with aminoglycosides due to rapid resistance.
    • Combined with clavulanic acid due to low resistance to normal beta-lactamases.
  12. Ureidopenicillins
    Combined with aminoglycosides for synergism.
  13. Zosyn
    broadest spectrum
  14. 1st generation cephalosporins
    resistance to acid degradation similar to aminopenicillins
  15. Cefaclor
    serum-sickness
  16. Ceftriaxone
    meningitis
  17. Cefuroxime axetil
    oxime makes more beta-lactamase resistant
  18. 2nd generation cephalosporins
    More stable ins olution that most cephalosporins
  19. Cephamycins
    Cefoxitin: Bacteroides
  20. Third generation oral cephalosporins
    Aminothiazole increase potency and spectrum of activity.
  21. Third generation parenteral cephalosporins
    • Aminothiazole
    • Good for meningitis
  22. Third generation parenteral cephalosporins
    Good for meningitis
  23. Fourth generation parenteral cephalosporins
    Zwitterion gives good cell wall penetration
  24. Ceftaroline (Fifth generation)
    MRSA
  25. Aztreonam
    Gram negative aerobes only due to lack of affinity for PBPs

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