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  1. What are the indications for thiazide diuretics (HCTZ)?
    HTN, CHF, renal calculi, diabetes insipidus, chronic renal failure, osteoporosis.
  2. True/False

    HCTZ contains a sulfonamide group as part of its chemical structure.
  3. How is HCTZ excreted in the body?
    Via renal elimination (secretion).
  4. What is the target MOA of HCTZ? At what part of the nephron does this take place?
    • Inhibits the Na/Cl cotransporter.
    • Distal convoluted tubule.

    *Also has weak CA inhibition
  5. True/False

    HCTZ may lead to hypocalcemia.
    • False.
    • Since the Na/Cl transporter is inhibited, tubular cells ramp up Na/Ca antiporter and Ca reabsorption is increased.
  6. When using HCTZ, what will happen to urine values of the following?

    H2O, NaCl, Ca, K, Mg
    • Increased: H2O, NaCl, K, Mg
    • Decreased: Ca
  7. True or False

    HCTZ is a relatively mild diuretic.

    It is only working with roughly 10% of glomerular filtrate due to its site of action.
  8. True or False

    HCTZ should not be used in patients prone to developing nephrolithiasis.

    Since more calcium is reabsorbed, there is less available in the urine to form a kidney stone.
  9. What are some adverse events associated with HCTZ?
    • Hypokalemia
    • Hyperuricemia
    • Carbohydrate intolerance?
    • Increased serum lipoproteins?
  10. True or False

    HCTZ is considered a "mainstay of therapy" for patients with HTN.
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Tarloff Shizzz for exam 2
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