Home > Preview
The flashcards below were created by user
on FreezingBlue Flashcards.
To what class of drugs does triamterene belong?
Potassium sparing diuretics.
What are the indications for triamterene?
Chronic liver failure, CHF, [combination?]
What is the target MOA of triamterene? Where is its site of action in the nephron?
- Blocker of epithelial Na channel (ENaC).
- [Late distal tubule?] and collecting duct.
What influences the expression of ENaC?
Aldosterone - a steroid hormone.
How does triamterene spare the loss of K while still acting as a diuretic?
By blocking ENaC, Na is not reabsorbed and pulls H2O with it as it is excreted in the urine. K does not diffuse out of the cell due to the net positive charge in the lumen from the excreted Na.
In addition to K being spared with triamterene, what other ion is also spared?
What adverse effects may be associated with triamterene?
- Folate antagonism (unique to triamterene)
- Hyperkalemia (as K is spared)
- Metabolic acidosis (as H+ is spared)
What can be combined with triamterene to avoid potential for hyperkalemia?
Thiazide or loop diuretics.
What happens to the levels of the following in the ECF?
Volume, NaCl, K, H
- Increase: K, H
- Decrease: Volume, NaCl
What is the diuretic capacity of triamterene?
About 3% NaCl (action is at the end of the nephron).
Home > Flashcards > Print Preview