Koavri Lectures Notes

The flashcards below were created by user Kjevans25 on FreezingBlue Flashcards.

  1. Describe the key characteristics of AIDs?
    • 1) it is characterized by the gradual destruction of cell mediated ( T cell ) immunity and autoimunity
    • 2) allows for opportunistic infections, viruses and cancers
    • 3) caused by HIV human immunodefiency virus type I and type II
    • 4) transmitted through body fluids including from a mother to child and infected blood or blood components
  2. What are the 3 types of pathophysiologic effects due to HIV infection?
    • Autoimmunity - prdt of Autoimmune Ab, Arthritis
    • Immunodeficiency- opportuntistic bacterial & viral infections ->cancerous
    • Neurologic dysfunction -AIDs denemtia complex, HIV encephalopathy
  3. Describe the 3 phases of HIV infection?
    • 1) Primary infection - syndrome of a fever, increased viral replication w/n 2-4weeks after exposure
    • 2) Latent phase - chronic asymptomatic phase, gradually falling CD4+ counts, median duration is 10yrs
    • 3) Overt AIDs -CD4+ count <200cells/uLs AIDs definining illness death can occur w/o treatment 2-3yrs
  4. What are some forms of diagnosis of HIV?
    • 1) the use of Enzyme-linked immunosorbent assay & western blotting to detect the presence of HIV Abs viral ab
    • 2) where normal CD4+ cell count is 1000-1200cells/uL the detection of CD4+ cell count<200cell/uL
    • 3) 1 or more conditions specified by the Centers for Disease Control & Prevention
  5. What are the primary forms of treatment for HIV?
    • 1) combination of 3 different types of antiretroviral agents to inhibit HIV viral replication
    • 2) use of 2 nucleosides + 1 protease inhibitor
    • 3) use of 2 nucleosides + 1 nonnucleoside
  6. What were some for of treatments that are used that were also use prior to antiviral drugs?
    • 1)Immunomodulatory agents
    • 2) Human granulocyte colony-stimulating growth factor
    • 3) Anti-infective agents
    • 4) Anti-neoplastic agents
    • 5) Supportive therapy( pain relief, psychological support, nutritional support, fluid & electrolyte therapy
  7. What are the key factors a physician monitors of infected HIV patients
    • 1) CD4+ cell count and viral load
    • 2) monitor drug resistance
    • 3) review of the systems of the body focusing on neurological factors ( CNS infection), visual changes, diarrhea, fever, shortness of breath
  8. What type of virus is AIDs classified as?
    RNA virus
Author
ID
73163
Card Set
Koavri Lectures Notes
Description
Last notes of Biochem
Updated
Show Answers