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awalczak11
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73234
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top 200
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2011-03-16 12:17:50
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top 200
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  1. Lipitor
    1.generic
    2.class
    3.MOA
    4.PC
    5.SE
    6.F
    7.DI,DC
    • 1.atorvastatin
    • 2.statin
    • 3.inhibits HMG-CoA reductase
    • 4. given anytime during the day due to long 1/2life
    • 5. myopathy, myalgia, rhabdomyolysis, increased LFT
    • 6. qd
    • 7. contraindicated in active or chronic liver disease
  2. Lescol XL
    • 1.fluvastatin
    • 2.statin
    • 3.inhibits HMG-CoA reductase
    • 4. given HS bc most cholesterol is produced at night
    • 5. myopathy, myalgia, rhabdomyolysis, increased LFT
    • 6. hs
    • 7. contraindicated in active or chronic liver disease
  3. Crestor
    • 1.rosuvastatin
    • 2.statin
    • 3.inhibits HMG-CoA reductase
    • 4. given HS bc most cholesterol is produced at night. adjust for pt with renal impairment (CrCL<30ml/min) and liver disease
    • 5. myopathy, myalgia, rhabdomyolysis, increased LFT
    • 6. hs
    • 7. contraindicated in active or chronic liver disease
  4. Niaspan
    • 1.niacin
    • 2.nicotinic acid (niacin)
    • 3.decrease VLDL synthesis, thus dicrease LDL and TG; may inhibit apolipoproteinA which increases HDL
    • 4. give aspirin 325 or ibuprofen 200mg 30min prior to dose to decrease itch and flush
    • 5.flush,hyperglycemia,hyperuricemia(gout)
    • 6. hs
    • 7. use in caution with resins(bile acids); combo with statin and lopid may increase risk of myopathy; do not is if pt has chronic liver disease or severe gout
  5. Tricor
    • 1.fenofibrate
    • 2.fibric acid
    • 3.decrease TG by reduction of apo-b; increase HDL by increasing apo-A1 and 2
    • 4.with or w/o food; decrease dose if pt has renal impairment
    • 5.dyspepsia,gallstones, myopathy(increased when used with statin)
    • 6.qd (48-145mg)
    • 7.warfarin,cyclosporine,bile acids decrease fibrate abs; do not use if pt has severe renal or hepatic impairment
  6. Lovaza
    • 1.omega 3 fatty acids
    • 2.omega
    • 3.decrease heaptic TG synthesis
    • 4.with food;avoid if allergic to fish;assess effectivness at 2months(d/c if TG are not decreased adequatily)
    • 5.burp, indigestion, backache, taste sense alteration
    • 6.4g qd or 2g bid (DF 1g)
    • 7.possible prolong bleeding may occur with anticoagulants
  7. Zetia
    • 1.ezetimibe
    • 2.cholesterol inhibitors
    • 3.inhibits cholesterol absorption at small intestine brush border
    • 4.with or w/o food, may be taken with statins
    • 5.increase liver enzymes, GI distress
    • 6. QD (10mg)
    • 7.cyclosporine increased zetia; combo with resins may decrease abs; combo with fibric acid may lead to gallbladder disease
    • DC:mod to severe heaptic disease
  8. Vytorin
    • 1.ezetimibe and simvastatin
    • 2.cholesterol inhibitor and statin
    • 3.inhibit cholesterol abs. at small intestine brush border;inhibit HMG-CoA reductase
    • 4. given HS
    • 5.increase LFT, myopathy,rhabdomyolysis, GI distress
    • 6.HS
    • 7.contraindicated in liver or heaptic disease
  9. Norvasc
    • 1.amlodipine
    • 2.CCB,dihydropyridine
    • 3.inhibits calcium influx into vascular smooth muscle and myocardium
    • 4.report dizzy,hypotension, increased swelling
    • 5.edema, flush, HA, gingivial hyperplasia
    • 6.QD
    • 7.grape juice
  10. Caduet
    • 1.amlodipine-atorvastatin
    • 2.CCB,statin
    • 3.inihbit calcium influx and HMG-CoA reducatse
    • 4.given daily
    • 5.myopathy,rhabdo,flush,HA,edema, increased LFT
    • 6.QD
    • 7.contraindicated in liver disease

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