Spironolactone

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Author:
jdonaldson
ID:
73354
Filename:
Spironolactone
Updated:
2011-03-16 20:34:18
Tags:
james donaldson James Donaldson usp USP
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  1. To which drug class does spironolactone belong?
    Mineralocorticoid antagonists / aldosterone antagonists
  2. What are the indications for spironolactone?
    Hyperaldosteronism, CHF, hypokalemia.
  3. What is spironolactone's target MOA? Where is its site of action?
    • Competitive antagonism of aldosterone.
    • Collecting tubule.
  4. What are some adverse effects associated with spironolactone?
    • Steroid effects (gynecomastia, hirsutism, peptic ulcers)
    • Hyperkalemia
    • Metabolic acidosis
  5. True or false?

    Most diuretics work on the apical membrane of tubular cells, while spironolactone exhibits its action on the basolateral membrane.
    True.
  6. True or false?

    Spironolactone interacts with a membrane bound receptor.
    False.

    Aldosterone is a steroid hormone, and has a cytoplasmic receptor that must enter the cell nucleus in order to exert its effects.

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