Renin Angiotensin System

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  1. What converts angiotensinogen to angiotensin I?
  2. What is the rate limiting enzyme in the formation of angiotensin II?
  3. What type of receptor on the juxtaglomerular cells of the kidneys can modulate renin release?
    Beta-1adrenergic receptors.
  4. What enzyme converts angiotensin I to angiotensin II?
  5. What agent in the renin-angiotensin system may lead to increased levels of aldosterone?
    Angiotensin II.
  6. What class of drugs block the release of renin from the kidneys?
    Beta blockers.
  7. What class of drugs inhibits the conversion of angiotensin I to angiotensin II?
    ACE inhibitors.
  8. Why do ACEIs lead to increased levels of bradykinin?
    Angiotensin converting enzyme also has a role in the degradation of bradykinin.
  9. What is the major target of angiotensin receptor blockers?
  10. Why does chronic stimulation of AT1-Rs lead to sodium retention?
    It is long-term compensation by the body to increase BP and ECF volume.
  11. What is another term for kininase II?
    Angiotensin converting enzyme.
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Renin Angiotensin System
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