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What is Hypoxia?
Inadequate oxygen to tissues
Why does hypoxia kill tissue?
Not enough O2 downs synth of ATP.
1. ATP synth occurs in inner Mito memb by oxidative phosphorylation.
2. O2 is electron acceptor at end of ETC, and lack O2=lack ATP synth.
Clinical findings of Hypoxia
3. cog impairment
Name the 5 causes of Tissue Hypoxia?
3. Ventilation defect
4. Perfusion defect
5. Diffusion defect
What is ischemia? What are the consequences? name some examples?
decrease arterial blood flow or venous ouflow of blood.
Examples: coronary art atherosclerosis, down CO, thrombosis of splenic vein
Consequences 1. Atrophy 2. INfarction of tissue (necrotic) 3. organ dysfxn (heart fail)
Chapter 1 Cell Injury