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What is Hypoxia?
Inadequate oxygen to tissues
Why does hypoxia kill tissue?
- Not enough O2 downs synth of ATP.
- 1. ATP synth occurs in inner Mito memb by oxidative phosphorylation.
2. O2 is electron acceptor at end of ETC, and lack O2=lack ATP synth.
Clinical findings of Hypoxia
- 1. Cyanosis
- 2. confused
- 3. cog impairment
- 4. lethargy
Name the 5 causes of Tissue Hypoxia?
- 1. Ischemia
- 2. Hypoxemia
- 3. Ventilation defect
- 4. Perfusion defect
- 5. Diffusion defect
What is ischemia? What are the consequences? name some examples?
decrease arterial blood flow or venous ouflow of blood.
Examples: coronary art atherosclerosis, down CO, thrombosis of splenic vein
Consequences 1. Atrophy 2. INfarction of tissue (necrotic) 3. organ dysfxn (heart fail)
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