Losartan

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Author:
jdonaldson
ID:
73487
Filename:
Losartan
Updated:
2011-03-17 10:55:49
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james James Donaldson donaldson usp USP
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  1. To what class of drugs does losartan belong?
    Angiotensin II receptor antagonist (ARBs)
  2. What are the indications for losartan?
    HTN
  3. True or false?

    Losartan is metabolized to its active form.
    True.
  4. What is losartan's target MOA?
    Competitive antagonism of AT-1 and AT-2 receptors.
  5. Losartan has higher affinity for (AT-1 / AT-2) receptors.
    AT-1
  6. True or false?

    Losartan's action is exhibited at the enzymatic level.
    False.

    Losartan works at the receptor level.
  7. True or false?

    The incidence of bradykinin cough and angioedema is roughly the same as with ACEIs.
    False.

    Although there is some cross-reactivity, the incidence of both is much lower.
  8. What are some adverse effects assoicated with losartan?
    • Orthostatic hypotension
    • Hypotension
    • Hyperkalemia
  9. True or False?

    Losartan can cross the placenta during pregnancy.
    True.
  10. What does it mean to say that losartan's active metabolite is a "pseudo-irreversible" antagonist of AT-1 receptors?
    The antagonism is reversible, but only over a long period of time.
  11. What did the ELITE study conclude?
    That ARBs were slightly better at preventing complications of heart conditions as compared to ACEIs.
  12. True or False?

    ARBs reduce the activation of AT-1 recetpors more effectively than ACEIs.
    True.
  13. True or False?

    ARBs allow activation of AT-2 receptors but ACEIs do not.
    True.

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