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Preferentially stimulates muscarinic receptors, esp. GI and Bladder. (increases conctractions)
Tends to predominately inhibit at the NM junction- Muscarinic
Name (2) drugs that may help with Alzheimer disease
- Tacrine (Cognex)
- Donepezil (Aricept)
Name (6) clinical applications of Cholinergic Stimulants
- Alzheimer disease
- GI and urinary bladder atony
- Myasthenia Gravis
- Reversal of neuromuscular blockage
- reversal of anticholinergic-induced CNS toxicity
What is the prototypical Antimuscarinic anticholinergic drug?
Where does it come from?
- from plants- belladonna and jimsonweed
- blocks postsynaptic cholinergic muscarinic receptor
Name (9) clinical applications of Antimuscarinic Drugs
- GI system
- Motion sickness
- Preopertative med
- urinary tract
- respirtatory tract
- cholinergic poisoning
Name (5) side effects of anticholinergic drugs
- dry mouth
- blurred vision
- urinary retention
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