Verapamil

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Author:
jdonaldson
ID:
73520
Filename:
Verapamil
Updated:
2011-03-17 14:20:03
Tags:
james James donaldson Donaldson usp USP
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Description:
Cotto!!!
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  1. To what class of drugs does verapamil belong?
    CCBs - Non DHP
  2. Target MOA: true or false?

    Verapamil more greatly affects myocardial tissue than nifedipine.
    True.
  3. What are the indications associated with verapamil?
    • HTN
    • Arrhythmia (antiarrhtyhmic agent class IV)
  4. Target MOA: to what type of calcium channel and where does verapamil exert its action?
    Blocks L-type calcium channels, specifically in the SA and AV nodes of the heart, reducing Ca++ influx and slowing calcium channel recovery.
  5. How does verapamil affect myocardial contractility, SA node rate and AV node conduction velocity?
    • Decreased myocardial contractility (negative inotrope).
    • Slows SA pacemaker rate and AV conduction velocity.
  6. What are some adverse effects associated with verapamil?
    • HA
    • Hypotension
    • Bradycardia / AV block
    • Constipation (via GI smooth muscle relaxation)
  7. True or false?

    Verapamil is a CCB that exerts its action on an extracellular site of calcium channels.
    • False.
    • Verapamil, unlike nifedipine, is targeted at an intracellular site on calcium channels.

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