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To what class of drugs does verapamil belong?
CCBs - Non DHP
Target MOA: true or false?
Verapamil more greatly affects myocardial tissue than nifedipine.
What are the indications associated with verapamil?
- Arrhythmia (antiarrhtyhmic agent class IV)
Target MOA: to what type of calcium channel and where does verapamil exert its action?
Blocks L-type calcium channels, specifically in the SA and AV nodes of the heart, reducing Ca++ influx and slowing calcium channel recovery.
How does verapamil affect myocardial contractility, SA node rate and AV node conduction velocity?
- Decreased myocardial contractility (negative inotrope).
- Slows SA pacemaker rate and AV conduction velocity.
What are some adverse effects associated with verapamil?
- Bradycardia / AV block
- Constipation (via GI smooth muscle relaxation)
True or false?
Verapamil is a CCB that exerts its action on an extracellular site of calcium channels.
- Verapamil, unlike nifedipine, is targeted at an intracellular site on calcium channels.