Phys #7.txt

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Author:
kepling
ID:
73573
Filename:
Phys #7.txt
Updated:
2011-03-17 19:21:29
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Phys
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Description:
Phys #7
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  1. In what zone of the lungs is blood flow the highest?
    Zone 3
  2. What is the P and R difference between the pulmonary and systemic flows?
    Pulmonary: Lower P and Lower R
  3. What is the major factor of Pulmonary blood flow regulation?
    PO2
  4. What is the effect on pulmonary BF when there is low PO2?
    Vasoconstriction (opposite of tissues)
  5. What causes pulmonary vasoconstriction?
    Lack of NO
  6. At high altitude, since there is low PO2 and pulmonary vasoconstricton, what happens to R and P?
    • R increases and P increases to maintain Flow
    • Q = P/R
  7. What makes Thromboxane and what is its function?
    • Made by Macrophages, Leukocytes, Endothelial cells
    • Causes Vasoconstriction
  8. What makes Leukotriene and what is its function?
    • Made by lipoxygenase
    • Function = Vasoconstriction
  9. What makes Prostacyclin and what is its function?
    • Made by Endothelial cells
    • Function = Vasodilate
  10. Which causes hypoxemis: R-L shunt or L-R shunt?
    R-L shunt (aka Tetrallogy of Fallot)
  11. In what region is alveolar ventilation highest?
    Zone 3, Base
  12. In what region is V/Q highest?
    Zone 1, Apex
  13. In what region is PaO2 highest?
    Zone 1, Apex
  14. In what region is PaCO2 highest?
    Zone 3, Base
  15. What happens to BF with High V/Q and Low V/Q?
    • High V/Q: BF decreases
    • Low V/Q: BF increases
  16. What happens to PO2 and PCO2 in the pulmonary capillaries with High and Low V/Q?
    • High V/Q: High PO2 and Low PCO2
    • Low V/Q: Low PO2 and High PCO2
  17. What two reasons cause a V/Q shunt?
    • R-L Shunt
    • Airwaye obstruction

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