GI pharm

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Author:
anddavis
ID:
73580
Filename:
GI pharm
Updated:
2011-03-17 20:37:34
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GI pharm
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GI pharm
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  1. Cimetidine
    • Reversible block of histamine H2 receptors -> decreased H secretion by parietal cells
    • Inhibitor of P-450, antiandrogenic effects, crosses BBB and placenta, decreased renal creatinine excretion
  2. Omeprazole
    PPI - irreversibly inhibits H/K ATPase in stomach parietal cells
  3. Bismuth, scralfate
    • Bind to ulcer base, provides protection, allos HCO3 secretion to reestablish pH gradient
    • Part of triple therapy for H pylori (with metronidazole and amoxicillin or tetracycline)
  4. Misoprostol
    • PGE1 analog - increases production and secretion of gastric mucous barrier, decreases acid production
    • Prevention of NSAID-induced peptic ulcers, maintenance of PDA, inducing labor
  5. Pirenzepine, propantheline
    • Muscarinic antagonists
    • Block M1 receptors on ECL cells (decreased histamine secretion) and M3 receptors on parietal cells (decreased H secretion)
    • Can cause tachycardia, dry mouth, difficulty focusing eyes
  6. Aluminum hydroxide
    Magnesium hydroxide
    Calcium carbonate
    • Constipation
    • Diarrhea
    • Hypercalcemia
    • All can cause hypokalemia
  7. Infliximab
    • Monoclonal Ab to TNF
    • Used in Crohn's disease, ulcerative colitis, rheumatoid arthritis
    • Can reactivate latent TB
  8. Sulfasalazine
    • Sulfapyridine (antibacterial) + 5-ASA (antiinflammatory)
    • Activated by colonic bacteria
    • Used for UC, Crohn's disease
    • Can cause reversible oligospermia
  9. Ondansetron
    • 5HT3 antagonist - central acting antiemetic
    • Can cause headache, constipation
  10. Metoclopramide
    • D2 receptor antagonist
    • Increased resting tone, contractility, LES tone, motility
    • Used in diabetic and post-surgery gastroparesis, N/V from chemo
    • Can have parkinsonian effects; contraindicated in SBO

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