Card Set Information
james James donaldson Donaldson usp USP
I'm the great bambino.
To what class of drugs does minoxidil belong?
What are the indications associated with minoxidil?
What is minoxidil's target MOA?
Activates K+ channels in vascular smooth muscle.
Target MOA: why does minoxidil's activation of K+ channels lead to vascular smooth muscle relaxation?
The efflux of K+ from smooth muscle cells causes hyperpolarization, making it more difficult to stimulate voltage gated calcium channels.
Minoxidil exerts its effect more greatly on (arterial/venous) blood vessels.
Arterial > venous.
How does minoxidil's MOA help to lower BP?
Relaxation of vascular smooth muscle leads to decreased peripheral vascular resistance
What are some adverse effects associated with minoxidil?
ECG - T wave changes
Hypertrichosis (abnormal hair growth)
Dry scalp, dandruff