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To what class of drugs does minoxidil belong?
What are the indications associated with minoxidil?
- Severe HTN
- Alopecia androgenetica
What is minoxidil's target MOA?
Activates K+ channels in vascular smooth muscle.
Target MOA: why does minoxidil's activation of K+ channels lead to vascular smooth muscle relaxation?
The efflux of K+ from smooth muscle cells causes hyperpolarization, making it more difficult to stimulate voltage gated calcium channels.
Minoxidil exerts its effect more greatly on (arterial/venous) blood vessels.
Arterial > venous.
How does minoxidil's MOA help to lower BP?
Relaxation of vascular smooth muscle leads to decreased peripheral vascular resistance
What are some adverse effects associated with minoxidil?
- ECG - T wave changes
- Peripheral edema
- Hypertrichosis (abnormal hair growth)
- Dry scalp, dandruff
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