- 1. Senna: widely used stim laxative.
- Its active ingredient is group of sennosides, natural complex of anthraquinone glycosides.
If take orally: causes bowel evac in 8-10h. also cause water and electrolyte secretion into bowel.
in combo with docusate stool softener, usefel for opioid induced constipation.
2. Bisacodyl: suppository or tablets
colon stimulant: acts on nerve fibers in mucosa of colon.
Side efx: ab cramps and possible atonic colon w/ chronic use.
Antacid can't be taken at same time: cause coated tablet to dissolve to early. Stomach irritate and pain.
3. Castor oil: broken down in sm int to ricinolenic acid, very irritating to gut, ups peristalsis.
avoid in preggers, may stim uterine contractions