Home > Preview
The flashcards below were created by user
on FreezingBlue Flashcards.
To what drug class does gemfibrozil belong?
- "Fibrates" -
- Fibric acid antilipemics
- PPAR-alpha antagonists
What is PPAR-alpha?
A nuclear transcription factor.
True or false?
The active site of gemfibrozil's chemical structure resembles a fatty acid.
What are the indications associated with gemfibrozil?
Types IV and V hyperlipidemia
True or false?
Gemfibrozil is more effective than statins, and the statins tend to be add-ons or alternative therapies to the fibrates.
Fibrates are typically alternatives or add-ons to the statins.
What is gemfibrozil's target MOA?
- Activates (agonist) PPAR-alpha and PPREs
- Mimics free fatty acids
Where is PPAR-alpha expressed in the body?
- Skeletal muscle
How does gemfibrozil's MOA lead to decreased triglycerides in the body?
- Increased muscle cell expression of LPL
- Increased uptake of triglyceride rich lipoproteins
- Decreased hepatic expression of ApoC-III (inhibitor of LPL)
- Increased transcription of apoA-I and II (HDL apolipoproteins)
Type IV hyperlipidemia is characterized by?
- IV: hypertriglyceridemia
- V: high VLDL and chylomicrons
What are some adverse effects associated with gemfibrozil?
- GI discomfort (most common)
- Gallstone formation (with older drugs from class)
The three overall outcomes from activation of PPAR-alpha by gemfibrozil are...
- 1.) Increased plasma HDL
- 2.) Decreased plasma triglycerides
- 3.) Decreased triglyceride synthesis
What would you like to do?
Home > Flashcards > Print Preview