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Acidemia vs Acidosis: What is the difference?
Acidemia is low BLOOD pH and acidosis is low TISSUE pH.
Inc AG Metabolic Acidosis: Causes?
- 1. Reduced Excretion (A/CRF) PO4, SO4
- 2. Increased Production
- a. Lactic acid (low O2, BP, Drugs -Cyanide, Iron, Metforman, ASA)
- b. Ketoacids (DKA, AKA)
- c. Drug Acids (oxalic, formic)
Mixed Acid/Base for DKA
- DKA (increased AG Metabolic acidosis 2nd)
- Lactic acidosis (poor perfusion 2nd dydratioin)
- Ketoacidosis (no intracellular glucose)
- Renal failure (PO4, SO4 accumulation)
Bicarb in Acidosis (Pros 3, Cons 5)
- OD�s (TCA, ASA, Methanol, ethylene glycol)
- Prolonged arrest (>15min)
- Specific (Rhabdo, kids)
- CI�d (DKA, Sepsis)
- Electrolytes (will reduce K, Ca, INC OSM+++)
- Liver (reduced metabolism of lactic, keto acids)
- CSF (increased acidosis)
- ODC (O2 dissociation curve � reduced o2 offloading)
- Cerebral (hypotension, stroke, sepsis)
- Drive (COAD)
- Cord (PNS (GB, MG, OGP, envenomation, electrolyte N,Ca)
- Chest (T/PTX, HemoPTX, Effusion, APO)
- Increased HR
- Reduced GCS >80mmHg