Pharm Exam 2
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what is the absorption, distribution, metabolism and excretion of a drug?
what is the mechanisms of drug action involving biochemical and physiologic effects of drugs
pharmacodynamics (science of molecular interactions between drugs and body constituents-mechanism of action)
t/f pharmacokinetics is the science of molecular interaction between drugs and bondy constituents
false of course PHARMACODYNAMICS
what are seven factors of a drug receptor? (yes yes just cheat this one is long and boring and impossible to memorize)
- cellular macromolecules
- locaiton on the cell surface or within the cell
- hundreds of different receptors on a single cell
- complimentary fit between drug and receptor
- electochemical charge
- hydrophic OR hydrophobic
- only one drug molecule can occulpy a receptor at one time
once a drug is taken how does it interact with a receptor?
the drug is delivered to the tissue of a cell, it forms a BOND between the DRUG MOLECULE and the DRUG RECEPTOR and the MECHANISM of ACTION follows the bond James Bond
what are the three phsyicochemical properties that infulence the movement of drug molecules across biologic membranes? think think think hmmm oh bother (yes yes winnie the pooh just popped in my head)
- molecular size
- lipid solubility
- degree of ionization
______ molecules are lipid soluble and pass throught the biologic membrane easily. ______ drugs are water soluble and must pass through water pores of hte biolgic membrane or be thrasported through by specialized ______ mechanisms (what are the four ways?)
- Transport-filitration, passive diffusion, facilitated diffusion, active transport)
t/f drugs can pass through the placenta
t/f the distribution of drugs to the CNS and cerebrospinal fluid is unrestricted by the blood brain barrier
false false false like always RESTRICTED BY BBB
what is a maintenance dose?
follows a loading doase and is consistent with the drug's half life
what is a loading dose
an initial high dose to quickly achieve a therapeutic blood level
t/f a maintenance dose is an initial high dose to quickly achieve a therapeutic blood level
false (surprised you shouldn't be) LOADING DOSE! load up on the drugs baby!
discuss the various factors involved in the biological variations of drug dosing
I don't know this answer by all means find it for me and let me know :D thanks have a nice day!
enteral absorption is influenced by the ______ of a drug (such as ____ soluble, ____ soluble, molecular _____ and pKa of the drug), ___ of the GI tract, presence of _____ in stomach, gastric motility, degree of splanchnic ____ flow, and pt _____ of taking the prescribed drug regimen
- lipid, water, weight
- FOOD (yum)
t/f the IV ROA bypasses the absorption phase
fffall...wait no thats TRUE
how is a drug that is inhaled absorbed?
pulmonary absorptive surfaces in lungs allow for rapid access of gaseous, voatile agents to the circulation
how are topical drugs absorbed?
through skin and mucosa by passive diffusion that ais proportional to their concentration and lipid solubility
Pharmacology for 200 Please. delay the dissolution of drug, dissolves in upper intestines instead of stomach, and reduces adverse gastric side effects.
What is Enteric Coating?
How would a greater blood flow of an area just as liver, heart and GI tract effect the absorption of a drug?
Faster rate of absorption
what is the site of absorption for most oral drugs?
upper small intestine
what is the safest, most common, convenient and most unpredictable ROA
in the liver the ___ ___ effect may reduce the concentration of drug molecules
if a drug is bound to _____ it has a greater protection against the metabolism of the liver know as?
- protein (albumin)
- FIRST PASS
what is th e most common means to eliminat drug molecules?
t/f phase II of metabolism makes drugs inactive
phase I and phase II of metabolism are collectively referred to as what?
what is the most commonly used pathway during metabolism of a drug
what does the cytocrom P450 enzyme syste do?
- INDUCED to increase drug metabolism
- INHIBITED to reduce rate of drug metabolism
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