Pharm Exam 2

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Author:
cassiedh
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73835
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Pharm Exam 2
Updated:
2011-03-19 10:53:52
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ch2part2
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chapter 2 part 2 objectives of love
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  1. what is the absorption, distribution, metabolism and excretion of a drug?
    pharmacokinetics
  2. what is the mechanisms of drug action involving biochemical and physiologic effects of drugs
    pharmacodynamics (science of molecular interactions between drugs and body constituents-mechanism of action)
  3. t/f pharmacokinetics is the science of molecular interaction between drugs and bondy constituents
    false of course PHARMACODYNAMICS
  4. what are seven factors of a drug receptor? (yes yes just cheat this one is long and boring and impossible to memorize)
    • cellular macromolecules
    • locaiton on the cell surface or within the cell
    • hundreds of different receptors on a single cell
    • complimentary fit between drug and receptor
    • electochemical charge
    • hydrophic OR hydrophobic
    • only one drug molecule can occulpy a receptor at one time
  5. once a drug is taken how does it interact with a receptor?
    the drug is delivered to the tissue of a cell, it forms a BOND between the DRUG MOLECULE and the DRUG RECEPTOR and the MECHANISM of ACTION follows the bond James Bond
  6. what are the three phsyicochemical properties that infulence the movement of drug molecules across biologic membranes? think think think hmmm oh bother (yes yes winnie the pooh just popped in my head)
    • molecular size
    • lipid solubility
    • degree of ionization
  7. ______ molecules are lipid soluble and pass throught the biologic membrane easily. ______ drugs are water soluble and must pass through water pores of hte biolgic membrane or be thrasported through by specialized ______ mechanisms (what are the four ways?)
    • Nonionized
    • Ionized
    • Transport-filitration, passive diffusion, facilitated diffusion, active transport)
  8. t/f drugs can pass through the placenta
    true
  9. t/f the distribution of drugs to the CNS and cerebrospinal fluid is unrestricted by the blood brain barrier
    false false false like always RESTRICTED BY BBB
  10. what is a maintenance dose?
    follows a loading doase and is consistent with the drug's half life
  11. what is a loading dose
    an initial high dose to quickly achieve a therapeutic blood level
  12. t/f a maintenance dose is an initial high dose to quickly achieve a therapeutic blood level
    false (surprised you shouldn't be) LOADING DOSE! load up on the drugs baby!
  13. discuss the various factors involved in the biological variations of drug dosing
    I don't know this answer by all means find it for me and let me know :D thanks have a nice day!
  14. enteral absorption is influenced by the ______ of a drug (such as ____ soluble, ____ soluble, molecular _____ and pKa of the drug), ___ of the GI tract, presence of _____ in stomach, gastric motility, degree of splanchnic ____ flow, and pt _____ of taking the prescribed drug regimen
    • characteristics
    • lipid, water, weight
    • pH
    • FOOD (yum)
    • blood
    • COMPLIANCE!
  15. t/f the IV ROA bypasses the absorption phase
    fffall...wait no thats TRUE
  16. how is a drug that is inhaled absorbed?
    pulmonary absorptive surfaces in lungs allow for rapid access of gaseous, voatile agents to the circulation
  17. how are topical drugs absorbed?
    through skin and mucosa by passive diffusion that ais proportional to their concentration and lipid solubility
  18. Pharmacology for 200 Please. delay the dissolution of drug, dissolves in upper intestines instead of stomach, and reduces adverse gastric side effects.
    What is Enteric Coating?
  19. How would a greater blood flow of an area just as liver, heart and GI tract effect the absorption of a drug?
    Faster rate of absorption
  20. what is the site of absorption for most oral drugs?
    upper small intestine
  21. what is the safest, most common, convenient and most unpredictable ROA
    oral
  22. in the liver the ___ ___ effect may reduce the concentration of drug molecules
    first pass
  23. if a drug is bound to _____ it has a greater protection against the metabolism of the liver know as?
    • protein (albumin)
    • FIRST PASS
  24. what is th e most common means to eliminat drug molecules?
    renal excretion
  25. t/f phase II of metabolism makes drugs inactive
    true
  26. phase I and phase II of metabolism are collectively referred to as what?
    biotransformation
  27. what is the most commonly used pathway during metabolism of a drug
    Cytochrome P450
  28. what does the cytocrom P450 enzyme syste do?
    • INDUCED to increase drug metabolism
    • INHIBITED to reduce rate of drug metabolism

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