Lidocaine

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Author:
jdonaldson
ID:
73924
Filename:
Lidocaine
Updated:
2011-03-19 20:57:05
Tags:
james James donaldson Donaldson usp USP
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Description:
Sheeee yooooo they give dis shizzzz at da dentifff office
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  1. To which class of drugs does lidocaine belong?
    Na+ channel blockers (Class 1B)
  2. How is lidocaine administered?
    By IV only.
  3. What indications are associated with lidocaine?
    • Local anesthesia
    • Arrhythmia (ventricular tachycardia)
  4. True or false?

    Lidocaine is converted to active metabolites.
    True.

    These active metabolites may cause CNS toxicity.
  5. What is lidocaine's target MOA?
    • Blocks the activated (open) and inactivated (refractory) stages of sodium channels. [does not effect the "closed" state]
    • Suppresses automaticity of conduction tissue.
    • Blocks initiation and conduction of nerve impulses.
  6. What does lidocaine do to myocyte action potentials?
    Lidocaine shortens myocyte action potentials.
  7. What does procainamide do to myocyte action potentials?
    Procainamide lenghens myocyte action potentials.
  8. As per lidocaine's MOA, what occurs in myocardial tissue?
    • Ventricular excitability is depressed, as stimulation threshold is increased.
    • Lidocaine has minimal effects on arterial BP and cardiac contractile force.
  9. What are some adverse effects associated with lidocaine?
    • Hypotension
    • CNS toxicity: paresthesias, tremor, dizziness, convulsions

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