Amiodarone

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Author:
jdonaldson
ID:
73997
Filename:
Amiodarone
Updated:
2011-03-20 12:38:10
Tags:
james James donaldson Donaldson usp USP
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Description:
Phlippians 2:3
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  1. To which class of drugs does amiodarone belong?
    K+ channel blocker/antiarrhythmic (Class III).
  2. True or false?

    Amiodarone is the "standard of care" for atrial arrhythmias.
    True.

    The rest of these antiarrhythmics are used on an emergency basis according to Dr. Whitman via Dr. Tarloff as per STC 145 through USP.
  3. What indications are associated with amiodarone?
    Ventricular and supraventricular arrhythmia.
  4. What is unique about the structure of amiodarone?
    It is amphoteric, with one side of the molecule being water soluble and the other side being lipid soluble.
  5. What is amiodarone's target MOA?
    • Blocks IKr and IKs potassium channels, prolonging phase 3 of myocardial action potentials (repolarization).
    • Also blocks inactivated Na+ channels.
    • Weak alpa- and beta-adrenergic blocking action.
    • Weak Ca++ channel blocking action.

    *Amiodarone fills all four antiarrhythmic classes.
  6. True or false?

    Amiodarone fits into all four classes of antiarrhythmics.
    True.
  7. As per amiodarone's MOA, what effects are experienced by the body's tissues?
    • Periperhal vasodilation from alpa- and beta- inhibition and Ca++ channel inhibition.
    • Slowed intra-cardiac conduction of action potential.
  8. What are some adverse effects associated with amiodarone?
    • Bradycardia
    • Heart block
    • Hypotension
    • Accumulation in heart, lungs, skin, and tears due to lipid solubility (Log P 7.9).
    • Pulmonary fibrosis, elevation of liver enzymes, photosensitivity, corneal microdeposits.
    • Blocked conversion of T3 to T4.
  9. True or false?

    Amiodarone, as the "standard of care" for arrhythmias, is often used long-term.
    False.

    Due to its many adverse effects (some of which are cumulative over time), it cannot be used in the long-term.

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