Digoxin

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Author:
jdonaldson
ID:
74006
Filename:
Digoxin
Updated:
2011-03-20 12:53:12
Tags:
james James donaldson Donaldson usp USP
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Description:
I'd like to get me some 'dig' please. Pleeaaazzzeeee.
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  1. True or false?

    One of the earliest signs of CHF is peri-orbital edema.
    False.

    One of the first signs of CHF is edema in the lower extremities.
  2. To which class of drugs does digoxin belong?
    Cardiac glycosides.
  3. What is the indication associated with digoxin?
    CHF
  4. What is unique about the chemical structure of digoxin?
    • It is a cardiac glycoside, with a single molecule containing:
    • - A sugar
    • - A steroid
    • - A lactone
  5. What is digoxin's target MOA?
    Inhibition of the Na+/K+ ATPase.

    As intracellular Na+ increases, the Na+/Ca++ exchanger ramps up to push Na+ out. Intracellular Ca++ increases, leading to faster depolarization and a shorter action potential.
  6. As per digoxin's MOA, what effect does this have on the body's tissues?
    • Increased cardiac contractility due to increased intracellular Ca++ (positive inotropy).
    • Suppression of AV node conduction (increase ERP).
    • Decreased conduction velocity.
  7. True or false?

    The therapeutic window for digoxin is considerably narrow.
    • True.
    • Therapeutic range: 0.5-1 ng/mL
    • Toxic range: 2 ng/mL and above
    • t1/2: 60 hours
  8. What are some adverse effects associated with digoxin?
    • Heart block
    • Premature ventricular contractions (PVCs)
    • ST segment depression
    • Rash
    • Blurred or yellow vision

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