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What can be interpreted from a high tranport rate (Tx)?
material was removed from ER by reabsorption
What can be interpreted from a negative tranport rate (Tx)?
material was added to ER by secretion
What can be interpreted form a Fractional Excretion ER/FL <1?
material was reabsorbed (ER has dropped from original FL)
What can be interpreted form a Fractional Excretion ER/FL >1?
material was secreted (ER rose from original FL)
What are the two routes of reabsorption transport?
What type of transport does glucose use to get from the apical to basolateral membrane?
Secondary active transport
What is the effect of AngII on Na reabsorption?
- 1) Activates Na/H pump
- 2) pushes H secretion
What is the effect of the SNS on Na reabsorption?
What is the effect of Parathyroid hormone on Na reabsorption?
- inhibites Na/Phosphate exchange
- pushes urinary phosphate excretion
What symptom is caused by mannitol?
Osmotic Diuresis b/c it can't be reabsorbed and it has to be accompanied by water. Na has to rediffuse into the lumen and bring more water in to excrete the Mannitol.
What happens to FL below Tubular Maximum?
What happens to FL above tubular maximum?
What is threshhold?
Moment when a substance begins to be seen in urine
What does decreasing GFR do to threshhold?
How does competition for organic anion transporters boost antibody treatment?
- Many organic ions will compete for the same transporter
- Different organic ions can be utilized to help stop secretion of valuable anions that would generally bind to the specific transporter
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