-
Vincristine
- Antineoplatic
- Inhibits the cell in M phase by inhibiting the formation of the mitotic spindle
- Tox: Peripheral neuropathy
-
Lomustine
- Antineoplastic alkylating agent
- Inhibets the crosslinking of DNA
- Crosses the blood brain barrier
- Tox: nausea, vomiting, mylosuppression, alopecia
-
Fosphenytoin
- Anticonvolsant
- Blocks the Na channels and inhibits an AP
- Tox: sedation, diploplia, Hersutism
-
Erlotinib
- EGFR tyrosine kinase inhibitor
- Works on non small cell carcinoma
- tox: rash, diarrhea
-
Gefinib
- EGFR tyrosine kinase inhibitor
- Works on non small cell carcinoma
- tox: rash, diarrhea
-
Temozolomide
- DNA alkylating agent
- Stops DNA cross linking
-
Hydrochlorothiazide
- Diuretic
- Inhibits the Na/Cl NCC symport in the DCT
- used in HTN, heart failure, hypercalciuria
- Tox: hyperkalemia. hpercalcemia
-
Rampiril
- ACE inhibitor
- stops the inactivation of bradykinin
-
Labetalol
- Alpha 1 and BEta 1,2 blocker
- anti-hypertensive
- tox: orthostatic hypotension
-
Edrophonium
- ChE inhibitor, indirect cholinomemetic
- 30 sec to 5 minutes of action
- used for Tensilon test
-
Azathioprine
- Immunosupressive
- prodrug of mer-captopurine
- interferes with purine nucleic acid metabolism
-
Mycophendate mofetil
- Purine antagonist
- Blocks GTP synthesis by inhibiting inosine monophosphate dehydrogenase
- immunosuppresent
- Tox: suppress B and T cell activation
-
Omeprazole
- Irreversibly blocks H/K pump in gastric parietal cells
- Used in peptic ulcers and GERD
- Short half life but long duration of action
- Tox: may reduce absorption of drugs
-
Infliximab
- Anti TNF-alpha
- Monoclonal antibody that binds to the TNF receptor and prevents binding
- Used in inflammitory bowel dissease, rheumatoid arthritis, sponylisis,
- Tox: hypersensitivity, infection, malignancy
-
-
Ibuprofen
- non selection NSAID
- reversible
- uses: close PDA, analgesia, antipyretic, anti-inflammatory
- Tox: Gastritis form blocking PGE2 which down regulated cAMP in gastric cells and stops acid production, nephrotoxin, anticoagulation
-
Clonidine
- A2 Agonist
- HTN, stops SANS outflow
- tox: rebound hypertension,
-
Repaglinide
- Insuline secretasogues, 4-5 hour duration
- Closes ATP sensitive K channels to increase AP and release insulin
- DM2
- tox: hyperglycemia, weight gain
-
Penicillin
- beta lactam antibiotic
- inhibits cell wall synthesis by binding cell surface receptors and triggering autolytic enzymes
- Tox hypersensitivity reaction
-
Alteplase
- recombonant throbolytic , t_PA
- tox: bleeding
-
Amlodapine
- Ca channel blocker, Dihydropyridine ( less cardiac effect)
- Vaso diolater by stopping Ca/calmodulin activation of MLCK
-
Metaprolol
- Beta blocker
- long acting
- used in angina, performance anxiety, HTN, Arrythmias
- tox: bronchspasm but less then other beta blockers
-
Ezetimibe
- Anti-hyperlipidemic, bile resin
- can cause hepatic damage
-
Simvastatin
- HMG Co-A reductase inhibitor
- Blocks cholesterol synthesis
-
Dipyridamole
- PDE inhibitor and adenosine receptor blocker on endothelium and RBC
- Increases intercellular platelet cAMP which down regulates the membrane presentation of gpIIa/IIIb receptors, stops plt aggregation
- Adenosine binds to membrane A2 receptors and activates adenyl cyclase
- tox:bleeding
-
Baclofen
- activates GABAb receptor
- inhibits spinal reflexes
- muscle relaxant and antispastic
- Tox: drowsiness and dizziness
-
Ondansetron
- seritonin blocker
- anti-emetic for cancer patients during chemo
- reduces vomiting
-
bethanechol
- direct acting muscurinic agonist
- M receptor increase IP2 and DAG
- used after surgery to initiate urination and deification
-
Pilocarpine
- direct acting muscurinic agonist
- increases salvation in Sjogrens syndrome, used in glocoma
- can cause vasoconstriction
-
Nicotine
- lipid soluble
- will activate ganglion of sympathetic and parasympathetic
- tachycardia, HTN, nausea, vomiting, diarrhea
-
Varenicline
- partial N agonist
- used in smoking cessation
- tox: HTN, diurrhea, pentral disterbance
-
Succinylcholine
- Nm receptor agonist
- muscle relaxant,
- depolarizing agent, causes small spasm then relaxation
- Rocuronium is a non depol relaxant
-
Neostigmine
- Indirect muscurinic agonist, carbamate
- reverses Nm blockage, treats MG
-
Pyridostigmine
- Indirect muscurinic agonist, carbamate
- treat MG
-
Physostigmine
- Indirect muscurinic agonist, carbamate
- reverse atropine poisoning and used in glaucoma
-
Parathion
- indirect muscurinic agonist, organophosphate
- used as insecticide
- highly lipid soluble
- all parasympathetic toxicities along with coma and muscle paralysis
-
malathion
- indirect muscurinic agonist, organophosphate
- used as insecticide but is safer since mammals can metabolize it to inactive products
-
Sarin, Tabun, diisopropyl flurophosphate
rapidly lethal nerve gas
-
Rivastigmine
- ChE inhibitor
- used in alzheimers disease
- tox: neusea and vomiting
-
Naltrexone
- Opiod receptor antagonist
- reduces relapse of ethanol
- tox: can cause withdrawal symptoms and decrease opiod effect
-
Acamprosate
- NMDA receptor antagonist
- reduces relapse risk
-
Disulfiram
inhibits aldehyde dehydrogrenase
-
Fomeprizole
- inhibits alcohol dehydrogenase
- used in methanol and ethylene glycol poisoning
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