Test 2 pharm.txt

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Author:
c_sopkovich
ID:
74555
Filename:
Test 2 pharm.txt
Updated:
2011-03-22 18:41:31
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parm
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PBL test 2
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  1. Vincristine
    • Antineoplatic
    • Inhibits the cell in M phase by inhibiting the formation of the mitotic spindle
    • Tox: Peripheral neuropathy
  2. Lomustine
    • Antineoplastic alkylating agent
    • Inhibets the crosslinking of DNA
    • Crosses the blood brain barrier
    • Tox: nausea, vomiting, mylosuppression, alopecia
  3. Fosphenytoin
    • Anticonvolsant
    • Blocks the Na channels and inhibits an AP
    • Tox: sedation, diploplia, Hersutism
  4. Erlotinib
    • EGFR tyrosine kinase inhibitor
    • Works on non small cell carcinoma
    • tox: rash, diarrhea
  5. Gefinib
    • EGFR tyrosine kinase inhibitor
    • Works on non small cell carcinoma
    • tox: rash, diarrhea
  6. Temozolomide
    • DNA alkylating agent
    • Stops DNA cross linking
  7. Hydrochlorothiazide
    • Diuretic
    • Inhibits the Na/Cl NCC symport in the DCT
    • used in HTN, heart failure, hypercalciuria
    • Tox: hyperkalemia. hpercalcemia
  8. Rampiril
    • ACE inhibitor
    • stops the inactivation of bradykinin
  9. Labetalol
    • Alpha 1 and BEta 1,2 blocker
    • anti-hypertensive
    • tox: orthostatic hypotension
  10. Edrophonium
    • ChE inhibitor, indirect cholinomemetic
    • 30 sec to 5 minutes of action
    • used for Tensilon test
  11. Azathioprine
    • Immunosupressive
    • prodrug of mer-captopurine
    • interferes with purine nucleic acid metabolism
  12. Mycophendate mofetil
    • Purine antagonist
    • Blocks GTP synthesis by inhibiting inosine monophosphate dehydrogenase
    • immunosuppresent
    • Tox: suppress B and T cell activation
  13. Omeprazole
    • Irreversibly blocks H/K pump in gastric parietal cells
    • Used in peptic ulcers and GERD
    • Short half life but long duration of action
    • Tox: may reduce absorption of drugs
  14. Infliximab
    • Anti TNF-alpha
    • Monoclonal antibody that binds to the TNF receptor and prevents binding
    • Used in inflammitory bowel dissease, rheumatoid arthritis, sponylisis,
    • Tox: hypersensitivity, infection, malignancy
  15. Quinapril
    • ACE inhibitor
    • HTN, CHD
  16. Ibuprofen
    • non selection NSAID
    • reversible
    • uses: close PDA, analgesia, antipyretic, anti-inflammatory
    • Tox: Gastritis form blocking PGE2 which down regulated cAMP in gastric cells and stops acid production, nephrotoxin, anticoagulation
  17. Clonidine
    • A2 Agonist
    • HTN, stops SANS outflow
    • tox: rebound hypertension,
  18. Repaglinide
    • Insuline secretasogues, 4-5 hour duration
    • Closes ATP sensitive K channels to increase AP and release insulin
    • DM2
    • tox: hyperglycemia, weight gain
  19. Penicillin
    • beta lactam antibiotic
    • inhibits cell wall synthesis by binding cell surface receptors and triggering autolytic enzymes
    • Tox hypersensitivity reaction
  20. Alteplase
    • recombonant throbolytic , t_PA
    • tox: bleeding
  21. Amlodapine
    • Ca channel blocker, Dihydropyridine ( less cardiac effect)
    • Vaso diolater by stopping Ca/calmodulin activation of MLCK
  22. Metaprolol
    • Beta blocker
    • long acting
    • used in angina, performance anxiety, HTN, Arrythmias
    • tox: bronchspasm but less then other beta blockers
  23. Ezetimibe
    • Anti-hyperlipidemic, bile resin
    • can cause hepatic damage
  24. Simvastatin
    • HMG Co-A reductase inhibitor
    • Blocks cholesterol synthesis
  25. Dipyridamole
    • PDE inhibitor and adenosine receptor blocker on endothelium and RBC
    • Increases intercellular platelet cAMP which down regulates the membrane presentation of gpIIa/IIIb receptors, stops plt aggregation
    • Adenosine binds to membrane A2 receptors and activates adenyl cyclase
    • tox:bleeding
  26. Baclofen
    • activates GABAb receptor
    • inhibits spinal reflexes
    • muscle relaxant and antispastic
    • Tox: drowsiness and dizziness
  27. Ondansetron
    • seritonin blocker
    • anti-emetic for cancer patients during chemo
    • reduces vomiting
  28. bethanechol
    • direct acting muscurinic agonist
    • M receptor increase IP2 and DAG
    • used after surgery to initiate urination and deification
  29. Pilocarpine
    • direct acting muscurinic agonist
    • increases salvation in Sjogrens syndrome, used in glocoma
    • can cause vasoconstriction
  30. Nicotine
    • lipid soluble
    • will activate ganglion of sympathetic and parasympathetic
    • tachycardia, HTN, nausea, vomiting, diarrhea
  31. Varenicline
    • partial N agonist
    • used in smoking cessation
    • tox: HTN, diurrhea, pentral disterbance
  32. Succinylcholine
    • Nm receptor agonist
    • muscle relaxant,
    • depolarizing agent, causes small spasm then relaxation
    • Rocuronium is a non depol relaxant
  33. Neostigmine
    • Indirect muscurinic agonist, carbamate
    • reverses Nm blockage, treats MG
  34. Pyridostigmine
    • Indirect muscurinic agonist, carbamate
    • treat MG
  35. Physostigmine
    • Indirect muscurinic agonist, carbamate
    • reverse atropine poisoning and used in glaucoma
  36. Parathion
    • indirect muscurinic agonist, organophosphate
    • used as insecticide
    • highly lipid soluble
    • all parasympathetic toxicities along with coma and muscle paralysis
  37. malathion
    • indirect muscurinic agonist, organophosphate
    • used as insecticide but is safer since mammals can metabolize it to inactive products
  38. Sarin, Tabun, diisopropyl flurophosphate
    rapidly lethal nerve gas
  39. Rivastigmine
    • ChE inhibitor
    • used in alzheimers disease
    • tox: neusea and vomiting
  40. Naltrexone
    • Opiod receptor antagonist
    • reduces relapse of ethanol
    • tox: can cause withdrawal symptoms and decrease opiod effect
  41. Acamprosate
    • NMDA receptor antagonist
    • reduces relapse risk
  42. Disulfiram
    inhibits aldehyde dehydrogrenase
  43. Fomeprizole
    • inhibits alcohol dehydrogenase
    • used in methanol and ethylene glycol poisoning

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