TRUE/FALSE: Phosphofructokinase is the rate-limiting enzyme of glycolysis. Its activity is enhanced by an acidic environment (low pH) and inhibited by an alkaline environment (high pH).
FALSE. Phosphofructokinase activity is inhibited by a low pH and enhanced by a high pH. Therefore, an increase in pH accelerates glycolysis and generates pyruvate and lactate. It follows that the generation of lactate in patients with lactic acidosis and the generation of ketoacids in patients with ketoacidosis are impeded by acidemia.