Antibiotics Mechanism and Resistance
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- MOA: Inhibit topoisomerase and dna gyrase
- Resistance: QnrA (prevent quinolone access to enzyme), AAC (acetylation: inactivation), QepA (efflux pump)
MOA: inhibit folic acid production and create false metabolites
- MOA: Binds to Ca and disrupt membrane
- Resistance: mprF (alter biochemical of organism), VISA (increase cell wall thickness, increase resistance), yycG (histidine inase), rpoC & rpoB (energy shifted from growth to cell wall)
- MOA: Binds Mg & disrupt membrane
- Resistance: Add sugar
MOA: binds to bacterial cytoplasmic membranes and alter osmotic barrier.
- MOA: inhibit Flipase
- Resistance: inducible
- MOA: inhibit translocation of amino acid (protein biosyntehsis)
- Resistance: erm (methylation decrease affinity of antibiotic to ribosome), mef (efflux pump), phosphorylation (destroy interaction between antibiotic and ribosome)
- MOA: Bind with Mg and block protein synthesis
- Resistance: efflux pump (Tet(O) kick tetracycline out), ribosomal protective protein (altered target, pick drug out), oxidative enzyme (energy dependent, modify drug)
- MOA: inhibit protein translation
- Resistance: TetX (oxidize H-donor bond and interupt binding activity)
- MOA: inhibit large and small subunit to come together
- Resistance: Methylation prevent H-bond with linezolid
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