CVR14

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  1. There are 3 main ways of regulating blood flow:
    • Intrinsic
    • Extrinsic
    • Paracrine
  2. Another word for intrinsic regulation of blood flow
    Autoregulation
  3. These are molecules which are made in one tissue and act on another tissue nearby
    Paracrine agent
  4. What are the two main mechanisms of autoregulation (intrinsic regulation)?
    • Myogenic
    • Metabolic
  5. This is an example of:
    Image Upload 1
    Myogenic regulation
  6. This is an example of:
    Image Upload 2
    Myogenic regulation
  7. Image Upload 3
    Metabolic regulation
  8. NO, PGI2, and Endothelium derived hyperpolarizing factor all have this effect on blood vessels
    vasodilation
  9. Endothelin has this effect on blood vessels
    vasoconstriction
  10. This enzyme (which is in the endothelium of blood vessels) makes NO
    endothelial NO synthase
  11. This amin acid is used in the making of NO (sounds like marginine)
    L-arginine
  12. How endothelial NO works:
    • NO is released from endothelium
    • it goes to the smooth muscle in the tunica media
    • it activates Gunalate Cyclase
    • GC converts GTP --> cGMP
    • cGMP is a second messenger
    • It reduces [Ca+ ] in the cell
    • causing vasodilation!
  13. What is the common name for Sildenafil?
    Viagra
  14. Image Upload 4
    Viagra inhibits cGMP phosphodiesterases
  15. Prostaglandins I, D, and E do this to blood vessels
    dilate
  16. Prostaglandins F and Thromboxane do this to blood vessels
    constrict
  17. How do Endothelium Derived Hyper-polarization factors work?
    They open K channels
Author
ID
74804
Card Set
CVR14
Description
Regulation of blood flow
Updated
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