Pcol 2 exam 3/4

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cindyx88
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74984
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Pcol 2 exam 3/4
Updated:
2011-04-19 19:04:31
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pcol exam immunosuppressants
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ms, immunosuppressants, sex hormones
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  1. Interferon beta SE and MAO
    • DOC, first line
    • they bind to lymphocytes, causes a reduction of the migration of t cells into the cns, reduce proliferation and reduction of cytokine production, fewer macrophages stimulated and less attack on myelin and oligogendrocytes
    • suppress the movement of t cells out of circ, generation of cytokines, inflamm that cytokines produce
    • SE
    • Suppress T cell activity--> high risk of opportunisitic infection
    • flu like symptoms
    • reduce wbc/rbc
    • depression/suicide thoughts
    • neutralizing antibodies develop (can lose its effects)
  2. Avonex
    • interferon- beta DMA
    • treatment of MS
  3. Rebif
    • interferon- beta DMA
    • treatment of MS
  4. Betaseron
    • interferon- beta, DMA
    • treatment of MS
  5. Glatiramer Acetate
    • Copaxone
    • treatment of MS
    • DMA
    • similar to myelin based proteins (protein integrated in myelin)
    • antibodies now attack this short peptide drug instead of the myelin
    • raise levels of helper tcells (helper tcells suppress killer t cells from moving into the cns)
    • similar to interferon
    • SE
    • Sub q qd
    • 15mins after admin pt is chest heavy (like mi/angina)
    • hard to breathe
    • contraindicated in pt w <3 problems
  6. Natalizumab
    • Tysabri
    • treatment of MS
    • DMA

    • infused monthly
    • monoclonal antibody against alpha 4 intergins on tcells
    • normally Alpha 4 beta 1 help with cell adhesion with this drug we reduce interaction between alpha beta and vcam1.. impair the interaction.. fewer adhesion/ cells moving into the blood stream

    • more efficacious than interferon and copaxone 2x
    • they cut clinical trails short because it was so good
    • SE
    • Progressive Multifocal leukoencephalopathy
    • -where a virus rises up and cause encephalitis (suppressing the immune system.. increase virus and bacteria).. taken off the market but put back on bc of how good it was.. pt must seek specific drs for this and monitored carefully
    • depression
  7. Dalfampridine
    • Ampyra
    • treatment of MS
    • NOT A DMA
    • reduces the effects of the demyelination, neurons are still being demyelinated by tcellls
    • PO
    • K channel blocker, keeps K in the neuron (improves neuronal conduction)
    • dont see less unmylenated, or plaques but see improvements of symps.. muscle strength/movement and walking (doesnt improve vision and speech)
    • SE
    • Seizures (cells more depolarized)
    • UTI
  8. Fingolimod
    • Gilenya
    • treatment of MS
    • DMA and PO
    • upon admin it gets phosphorylated
    • agonist at the S1P1 (help tcells move out of the lymphocytes and thymus) receptor, desensitize it, now they cant respond to S1P.. Tcells wont move out of the thymus or lymph nodes.. reduction of tcells in circ
    • SE
    • first dose phenomenon (bradycardia.. decrease HR.. has nothing to do with the vessels like in alpha 1 antag)
    • S1P is found throughout the body (smooth and cardiac muscle)
    • LONG TERM SE
    • hypertension, Seizures, swelling of retina, inflam bronchial, URTI
  9. Mitoxantrone
    • Novantrone
    • treatment of seconday MS
    • anticancer drug, kills killer tcells
    • antineoplastic drug, not used for relapsing remitting MS
    • SE
    • dose related cumulative cardiotoxicity (irreversible).. based on body SA.. bc of heart size
  10. Cyclosporine
    • Sandimmune, Neoral, Restasis
    • Immunosuppressants
    • interacts w cyclophilin= inhibits calcineurin --> less dephosphorylation of nfat= less nfat in nucelus for t cell proliferation
    • met by 3A4.. many DI
    • ADR
    • hypertention, nephrotoxic, cholesterol, hiritisum, gingival hyperplasia
  11. Tacrolimus
    • Prograf, Protoptic (cream)
    • Immunosuppressants
    • calcineurin inhib- binds to FKBP
    • ADR
    • hypertension, nephrotoxic, hyperglycemia, seizures
  12. Pimecrolimus
    • Elidel cream
    • Immunosuppressants
    • calcineurin inhib
  13. Sirolimus
    • Rapamune
    • Immunosuppressants
  14. Azathioprine
    • Imuran
    • Immunosuppressants
  15. Mycophenolate mofetil
    • Cellcept, Myfortic
    • Immunosuppressants
  16. Daclizumab
    Immunosuppressants
  17. Basiliximab
    Immunosuppressants
  18. Muromonab-CD3
    Immunosuppressants
  19. Methotrexate
    Traditional DMARDs
  20. Leflunomide
    • Arava
    • Traditional DMARDs
  21. Sulfasalazine
    Traditional DMARDs
  22. Hydroxychloroquine
    • Plaquenil
    • Traditional DMARDs
  23. Gold
    • Auranofin, solganol
    • Traditional DMARDs
  24. Penicillamine
    Traditional DMARDs
  25. Azathioprine
    • Imuran
    • Traditional DMARDs
  26. Cyclosporine
    Traditional DMARDs
  27. Enbrel
    • etanercept
    • Biological DMARDs
  28. Remicade
    • Infliximab
    • Biological DMARDs
  29. Humira
    • Adalimumab
    • Biological DMARDs
  30. Cimzia
    • Certolizumab
    • Biological DMARDs
  31. Simponi
    • Golimumab
    • Biological DMARDs
  32. Kineret
    • Anakinra
    • Biological DMARDs
  33. Actemra
    • Tocilizumab
    • Biological DMARDs
  34. Orencia
    • Abatacept
    • Biological DMARDs
  35. Sulfasalazine
    • IBD
    • Aminosalicylates
  36. Olsalazine
    • Dipentum
    • IBD
    • Aminosalicylates, 2nd gen
  37. Balsalazide
    • Colazal
    • IBD
    • Aminosalicylates, 2nd gen
  38. Mesalamine
    • Asacol, Pentasa, Rowasa, Canasa
    • IBD
    • 5-Aminosalicylates
  39. Budesonide
    • Entocort EC
    • IBD
    • Corticosteroids
  40. Azathioprine
    • IBD
    • Immunosuppressants
  41. Cyclosporine
    • IBD
    • Immunosuppressants
  42. Methotrexate
    • IBD
    • Immunosuppressants
  43. Remicade
    • IBD
    • Immunosuppressants
  44. Metronidazole
    • IBD
    • antibiotics
  45. Ciprofloxacin
    • IBD
    • antibiotics
  46. Estradiol
    • Estrace, Climara, Vivelle
    • Estrogen receptor agonist for HRT
  47. Estrone/ estropiprate
    • Ogen
    • Estrogen receptor agonist for HRT
  48. Conjugated estrogens
    • Premarin
    • Estrogen receptor agonist for HRT
  49. Esterified estrogens
    • Menest
    • Estrogen receptor agonist for HRT
  50. Synthetic Conjugated estrogens
    • Cenestin, Enjuvia
    • Estrogen receptor agonist for HRT
  51. Estrogen
    • Vagifem, Estring, Femring
    • Estrogen receptor agonist for HRT
  52. Raloxifene
    • Evista
    • Selective Estrogen Receptor Modulators
  53. Tamoxifen
    • Nolvadex
    • Selective Estrogen Receptor Modulators
  54. Toremifene
    • Fareston
    • Selective Estrogen Receptor Modulators
  55. Fluvestrant
    • Faslodex
    • SERD
    • Selective Estrogen Receptor Modulators
  56. Medroxyprogesterone acetate
    • Provera
    • Progestin receptor agonist for HRT
  57. Norethindrone
    • Aygestin
    • Progestin receptor agonist for HRT
  58. Progesterone
    • Prometrium, Crinone
    • Progestin receptor agonist for HRT
  59. Prempro
    • Combinations of estrogens and progestin
    • Progestin receptor agonist for HRT
  60. Femhrt
    • Combinations of estrogens and progestin
    • Progestin receptor agonist for HRT
  61. Climara Pro
    • Combinations of estrogens and progestin
    • Progestin receptor agonist for HRT
  62. Combipatch
    • Combinations of estrogens and progestin
    • Progestin receptor agonist for HRT
  63. Ethinyl estradiol
    Estrogen in contraceptves
  64. Mestranol
    Estrogen in contraceptves
  65. Medroxyprogesterone
    Progestin in contraceptves
  66. Norgestrel
    Progestins in contraceptives
  67. Levonorgestrel
    • Plan B
    • Progestin in contraceptves
  68. Norethindrone
    Progestin in contraceptves
  69. ethynodiol
    Progestin in contraceptives
  70. norgestimate
    Progestin in contraceptives
  71. Desogestrel
    Progestin in contraceptives
  72. Drosperinone
    Progestin in contraceptives
  73. Mifepristone
    • RU-486
    • Progesterone receptor antagonist
  74. Clomiphene
    • Clomid
    • Estrogen receptor antagonist
  75. FSH
    • Gonadotropins
    • Recombinant or purified
  76. LH
    • Gonadotropins
    • Recombinant or purified
  77. hcg
    • Gonadotropins
    • Recombinant or purified
  78. Menotropins
    Gonadotropins
  79. Gonadorelin
    • synthetic GnRH
    • Gonadotropins
  80. Ganirelix
    GnRH receptor antagonist
  81. Cetrorelix
    GnRH receptor antagonist
  82. Testosterone
    • Depo testosterone, Androderm patch, androgel, Testim
    • Androgen
  83. Methyltestosterone
    Androgen
  84. Danocrine
    Androgen
  85. Fluoxymesterone
    • Halotestin
    • Anabolic steroids
  86. Oxandrolone
    Anabolic steroids
  87. Oxymetholone
    Anabolic steroids
  88. Stanozolol
    • Winstrol
    • Anabolic steroids
  89. Nandrolone
    • Deca Durabolin
    • Anabolic steroids
  90. Abarelix
    GnRH receptor antagonist
  91. Leuprolide
    • Lupron
    • GnRH receptor agonists
  92. Nafarelin
    GnRH receptor agonists
  93. Goserelin
    GnRH receptor agonists
  94. Buserelin
    GnRH receptor agonists
  95. Histrelin
    GnRH receptor agonists
  96. Triptorelin
    GnRH receptor agonists
  97. Finasteride
    • Propecia, Proscar
    • 5-alpha reductase inhibitors
  98. Duasteride
    • Avodart
    • 5-alpha reductase inhibitors
  99. Flutamide
    • Androgen receptor antagonists
    • Eulexin
  100. Bicalutamide
    • Casodex
    • Androgen receptor antagonists
  101. Nilutamide
    • Androgen receptor antagonists
    • Nilandron
  102. Human recombinant Growth Hormones
    • Somatropins, Somatrem
    • Growth hormones
  103. Sermorelin
    Growth hormones
  104. Recombinant human IGF-1
    Growth hormones
  105. Octreotide
    • Sandostatin
    • Growth hormones
  106. Pegvisomant
    • Somavert
    • Growth hormones
  107. Estrogens
    • Anti-resorptivedrugs
    • Osteoporosis
  108. Raloxifene
    • Anti-resorptivedrugs
    • Osteoporosis
  109. Bisphosphonates
    • Anti-resorptivedrugs
    • Osteoporosis
  110. Calcitonin
    • Anti-resorptivedrugs
    • Osteoporosis
  111. Calcium
    • Anti-resorptivedrugs
    • Osteoporosis
  112. Vitamin D
    • cholecalciferol(D3), ergocalciferol(D2), calcitriol
    • Anti-resorptivedrugs
    • Osteoporosis
  113. Teriparatide
    • Forteo
    • Anabolic
    • osteoporosis
  114. Lispro
    • Humalog
    • Rapid acting insulin
  115. Aspart
    • Novolog
    • Rapid acting insulin
  116. Glulisine
    • Apidra
    • Rapid acting insulin
  117. HumulinR, NovolinR
    Regular Short acting insulin
  118. HumulinN, NovolinN
    • intermediate acting insulin
    • NPH
  119. Glargine
    • Lantus
    • Long acting insulin
  120. Detemir
    • Levemir
    • Long acting insulin
  121. Pramlintide
    • Symlin
    • diabetes
  122. Metformin
    • Glucophage
    • diabetes
  123. Rosiglitazone
    • Avandia
    • thiazolidinediones
    • Diabetes
  124. Pioglitazone
    • Actos
    • thiazolidinediones
    • Diabetes
  125. Acarbose
    • Precose
    • alpha-glucosidase inhibitors
    • diabetes
  126. Miglitol
    • Glyset
    • alpha-glucosidase inhibitors
    • Diabetes
  127. Chlorpropamide
    • insulin secretagogues
    • Sulfonylureas
    • Diabetes
  128. Glyburide
    • Micronase
    • insulin secretagogues
    • Sulfonylureas
    • Diabetes
  129. Glimpepiride
    • Amaryl
    • insulin secretagogues
    • Sulfonylureas
    • Diabetes
  130. Repaglinide
    • Prandin
    • insulin secretagogues
    • Meglitinides
    • Diabetes
  131. Nateglinide
    • Starlix
    • insulin secretagogues
    • Meglitinides
    • Diabetes
  132. Exenatide
    • Byetta
    • insulin secretagogues
    • GLP-1 receptor agonists
    • Diabetes
  133. Liraglutide
    • Victoza
    • insulin secretagogues
    • GLP-1 receptor agonists
    • Diabetes
  134. Sitagliptin
    • Januvia
    • insulin secretagogues
    • DPP-IV inhibitors
    • Diabetes
  135. Saxagliptin
    • Onglyza
    • insulin secretagogues
    • DPP-IV inhibitors
    • Diabetes
  136. Levothyroxine
    • Synthroid, Levoxyl, Levothroid, Unithroid
    • Thyroid hormone preparations
    • T4
  137. Liothyronine
    • Cytomel
    • Thyroid hormone preparations
    • T3
  138. Liotrix
    • Thyrolar
    • Thyroid hormone preparations
    • T3+T4
  139. Desicated Thyroid
    Thyroid hormone preparations
  140. Propylthiouracil
    • PTU
    • Anti-thyroid
  141. Methimazole
    anti-thyroid
  142. Thiocyanate
    • ionic inhibitors
    • antithyroid
  143. Perchlorate
    • ionic inhibitors
    • antithyroid
  144. Lugol's solution
    Iodide, antithyroid
  145. SSKI
    Iodide, antithyroid
  146. I131
    Radioactive iodide
  147. Prochlorperazine
    • Compazine
    • D2 receptor antagonist
    • Anti-emetics
  148. Trimethobenzamide
    • Tigan
    • D2 receptor antagonist
    • Anti-emetics
  149. Promethazine
    • Phenergan
    • D2 receptor antagonist
    • Anti-emetics
  150. Ondansetron
    • Zofran
    • 5-HT3 receptor antagonist
    • Anti-emetics
  151. Granisetron
    • Kytril
    • 5-HT3 receptor antagonist
    • Anti-emetics
  152. Dolasetron
    • Anzemet
    • 5-HT3 receptor antagonist
    • Anti-emetics
  153. Palonosetron
    • Aloxi
    • 5-HT3 receptor antagonist
    • Anti-emetics
  154. Metoclopramide
    • Reglan
    • Anti-emetic
  155. Cisapride
    anti-emetic
  156. Aprepitant/ Fosaprepitant
    • Emend
    • NK-1 receptor antagonist
    • Anti-emetics
  157. Dronabinol
    • Marinol
    • CB-1 receptor agonist
    • Anti-emetics
  158. Nabilone
    • Cesamet
    • CB-1 receptor agonist
    • Anti-emetics
  159. Alosetron
    • Lotronex
    • Irritable bowle syndrome
  160. Lubiprostone
    • Amitiza
    • Irritable bowle syndrome
  161. Misoprostol
    • Cytotec
    • PGE2 receptor agonist
    • anti-ulcer
  162. Sucralfate
    anti-ulcer
  163. Cimetidine
    • Tagamet
    • H2 receptor antagonist
    • anti-ulcer
  164. Ranitidine
    • Zantac
    • H2 receptor antagonist
    • anti-ulcer
  165. Nizatidine
    • Axid
    • H2 receptor antagonist
    • anti-ulcer
  166. Famotidine
    • Pepcid
    • H2 receptor antagonist
    • anti-ulcer
  167. Omeprazole
    • Prilosec/ Zegerid
    • Proton pump inhibitors
    • Anti-ulcers
  168. Esomeprazole
    • Nexium
    • Proton pump inhibitors
    • Anti-ulcers
  169. Lansoprazole
    • Prevacid
    • Proton pump inhibitors
    • Anti-ulcers
  170. Dexlansoprazole
    • Kapidex
    • Proton pump inhibitors
    • Anti-ulcers
  171. Rabeprazole
    • Aciphex
    • Proton pump inhibitors
    • Anti-ulcers
  172. Pantoprazole
    • Protonix
    • Proton pump inhibitors
    • Anti-ulcers
  173. Xolair
    • Omalizumab
    • Anti-IgE therapy
    • Drugs that interfere with the hypersensitivity reaction
  174. Cromolyn
    • Mast cell stabilizers
    • Drugs that interfere with the hypersensitivity reaction
  175. Nedocromil
    • Mast cell stabilizers
    • Drugs that interfere with the hypersensitivity reaction
  176. Epinephrine
    • Drugs that interfere with the hypersensitivity
    • reaction
  177. Diphenhydramine
    • Benadryl
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  178. Clemastine
    • Tavist
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  179. Dimenhydrinate
    • Dramamine
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  180. Chlorpheniramine
    • Chlor-Trimeton
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  181. Brompheniramine
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  182. Hydroxyzine
    • Atarax/Vistaril
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  183. Cyclizine
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  184. Meclizine
    • Antivert
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  185. Promethazine
    • Phenergan
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  186. Cyproheptadine
    • Periactin
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  187. Doxepin
    • First generation
    • H-1 receptor antagonist (anti-histamines)
  188. Loratidine
    • Claritin
    • second generation
    • H-1 receptor antagonist (anti-histamines)
  189. Desloratidine
    • Clarinex
    • second generation
    • H-1 receptor antagonist (anti-histamines)
  190. Cetirizine
    • Zyrtec
    • second generation
    • H-1 receptor antagonist (anti-histamines)
  191. Azelastine
    • Astelin
    • second generation
    • H-1 receptor antagonist (anti-histamines)
  192. Fexofenadine
    • Allegra
    • second generation
    • H-1 receptor antagonist (anti-histamines)

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