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Picornaviridae's virion is ___________.
Picornaviridae's genome is ___________.
Linear (+) ssRNA
Picornaviridae's genome features _____________.
5' NTR with IRES, VPg, and a poly A tail
Picornaviridae's genes are translated___________.
Ttranslated as 1 polyprotein that is autocatalytically cleaved by viral proteinases.
Autocatalytic cleavage works by _________, which is why________?
As picornaviridae's genome is translated, the secondary structure folds and forms a proteinase while still part of the polyprotein. This section of the protein cleaves itself and acts as a proteinase for other regions which frees up other proteinases and individual proteins. For this reason a complete full-length polyproteins are rarely found.
Examples of diseases caused by Picornaviridae include ________.
- Hepatitis A
Picornaviridae's distinct characteristics include _______, __________, ___________.
- Translation begins at IRES
- Autoproteolytic cleavage
- RNA replication is associated with vesicles in the cytoplasm.