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Flaviviridae's virion is ___________.
Icosahedral and enveloped
Flaviviridae's envelope is characterised by ____________.
Glycoproteins with icosahedral symmetry
Flaviviridae's genome is _________.
Linear (+) ssRNA
Flaviviridae's genome features _______.
a 5' cap an no poly A tail.
Flaviviridae's genes are translated ___________ and ____________.
as 1 polyprotein that is that is processed by viral and cellular proteinases
NS2/3 is_________ to create ______ which is a ______.
A nonstructural autoprotease that cleaves at the NS2/3 junction to make NS3/4 which is a bifunctional protein for polyprotein processing and RNA rep
Diseases caused by Flavi include _______...
- Yellow fever
- Dengue Fever
- Hepatitis C
Flaviviridae's distinct characteristics include ______, ________, __________, ________.
- Vector transmission (not hep C)
- Major envelope protein (E1/2) is parallel to lipid membrane
- Pesti and Hepaci have IRES
- Virions assemble by budding at the ER and are released by exocytosis
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