Card Set Information
Lupus PHPR524 Test5
What is the clinical presentation of lupus?
AND MANY MORE!!!
What is the epidemiology of lupus?
Most prevalent in young females
Less prevalent in whites
Peak onset between late teens and early 40s (but can even occur in kindergartners)
What is the etiology of lupus?
No single cause
multiple genes involved
loci appear to co-localize with loci of other autoimmune diseases
What are the risk factors/exacerbation factors for lupus?
Alfalfa sprouts (l-canavanine)
High intake of saturated fats
Estrogen (for those with APS also)
What is the pathophysiology of lupus?
Multiple autoantibodies react with various components of the cell nucleus
Immune complexes may be present for years before sx appear
Autoantibodies and complexes bind to target tissues, activating inflammation and phagocytosis, causing irreversible tissue damage
What are the complications of lupus?
Antiphospholipd syndrome (APS)(thrombosis)
Accelerated atherosclerosis (increased risk for cardiovascular and cerebrovascular diseases)
Other autoimmune diseases (Sjogren's, Scleroderma, etc)
What is the non-pharmacologic therapy for lupus?
Balanced routine of rest and exercise (fatigue management)
Avoid alfalfa sprouts and other foods containing l-canavanine
Avoid sunlight and use sunscreen with no PABA ingredients (Sulfa-related)
What drugs are used for lupus?
Systemic or Oral corticosteroids
Cyclophosphamide (lupus nephritis)
Azathioprine (lupus nephritis)
Mycophenolate (lupus nephritis)
DHEA (androgen/estrogen synthesis)
What are the special considerations for antimalarials?
Hydroxychloroquine preferred over Chloroquine
For long term management (slow onset)
For moderate musculoskeletal sx not controlled by NSAIDs (arthralgia/arthritis)
Stop if no response after 6 months
What is the usual initial therapy for Arthritis in lupus pts?
What is the usual initial therapy for pleurisy and pericarditis in lupus pts?
What is the usual initial therapy for rash in lupus pts?
What is the usual initial therapy for lupus nephritis?
What is the only possible drug therapy for fatigue in lupus pts?
What drugs can be used for rash in lupus pts?
Topical steroid (preferred)
What drugs can be used for arthritis in lupus pts?
What drugs can be used for pleurisy and pericarditis in lupus pts?
What drugs can be used for lupus nephritis?
Systemic steroid (preferred)
What are some other therapeutic considerations for lupus pts?
Influenza and pneumococcal vaccinations (infection risk)
Lifestyle modifications and medications for HTN, DM, and hyperlipidemia to decrease cardiovascular/cerebrovascular events