Card Set Information
Rheumatoid Arthritis PHPR524 Test5
What are the sx of RA?
Slow insidious onset
MCP and PIP joints
Felty's Syndrome (triad of RA, splenomegaly, and neutropenia)
Which agents used to treat RA are adjunctive therapy?
Which agents used to treat RA are disease-modifying?
What is the MOA of NSAIDs in RA?
Inhibition of COX to assist with reducing pain, stiffness and inflammation
What are the SE of NSAIDs?
GI upset and ulceration
What other analgesics may be used for pain relief in RA?
What are the NSAIDs used in RA?
What are oral corticosteroids used for in RA?
Continuous low-dose therapy
Short-term bursts for flare-ups
What are injectable corticosteroids used for in RA?
Less frequent dosing
IM depots up to 6wks
IA depots a few months
What are the limiting SE of corticosteroid therapy in RA?
How long does it take to see benefit from DMARDs in RA?
weeks to months
How are DMARDs used in combination therapy in RA?
Never more than one Biologic agent
Non-biologics + 1 biologic
When are biologic DMARDs typically used in RA?
After failure or intolerability of non-biologics
What are the non-biologic DMARDs used in RA?
Leflunomide (2nd line)
What are the recommended non-biologic DMARD combinations for RA?
MTX + HCQ and/or SSZ
SSZ + HCQ
What are the biologic DMARDs used in RA?