Osteoarthritis

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Author:
giddyupp
ID:
75139
Filename:
Osteoarthritis
Updated:
2011-03-25 02:34:52
Tags:
Osteoarthritis PHPR524 Test5
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Description:
Osteoarthritis
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  1. What are the risk factors for OA?
    • Obesity
    • Previous occupation
    • Certain sports
    • Hx of joint trauma
    • Genetics
  2. What is the MOA of APAP in OA?
    Inhibition of prostaglandins in the CNS
  3. What is the MOA of NSAIDs in OA?
    Inhibition of prostaglandins in the periphery by blocking COX
  4. What is the MOA of Glucosamine/Chondroitin in OA?
    Stimulates proteoglycan synthesis from cartilage in vitro
  5. What is the MOA of Tramadol in OA
    Centrally acting opioid analgesic
  6. What is the MOA of opioids in OA?
    Opioid agonism
  7. What is the MOA of capsaicin in OA?
    Depletion of substance p from nociceptive nerve fibers
  8. What is the MOA of topical NSAIDs in OA?
    blocks local COX-2 in the tissues
  9. What is the MOA of methylsalicylate in OA?
    counter irritation
  10. What is the MOA of intra-articular corticosteroids in OA?
    Anti-inflammatory
  11. What is the MOA of hyaluronate in OA?
    thickens the fluid in the joints
  12. What are the SE of APAP?
    • hepatotoxicity
    • nephrotoxicity
  13. What are the SE of NSAIDs?
    • Nausea
    • Abdominal pain
    • Diarrhea
    • GI bleed
    • Nephrotoxicity
    • Hepatitis
    • Fluid retention
  14. What are the SE of COX2 inhibitors?
    • Increased risk of CV events
    • Renal disease
  15. What are the SE of glucosamine/chondroitin?
    • Gas
    • Bloating
    • Nausea
  16. What are the SE of tramadol?
    • NV
    • Constipation
    • Somnolence
  17. What are the SE of intra-articular corticosteroids?
    • Infection
    • Osteonecrosis
    • Tendon rupture
  18. What are the SE of opioids?
    • NV
    • Constipation
    • Somnolence
  19. What are the SE of capsaicin?
    • Burning
    • Stinging
    • Erythema
  20. What are the SE of topical NSAIDs?
    dermatitis
  21. What are the SE of methylsalicylate?
    irritation
  22. What are the SE of hyaluronate?
    • Joint swelling
    • Rash
    • Pruritis
  23. What are the DI of APAP?
    • INH
    • Warfarin
  24. What are the DI of NSAIDs?
    • Li
    • Warfarin
    • PO hypoglycemics
    • Hi-dose MTX
    • ACEI
    • BBL
    • Diuretics
  25. What are the DI of COX2 inhibitors?
    CYP450

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