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A synthetic steroid with potent anti-inflammatory properties.
Mechanism of Action
Potent anti-inflammatory properties and inhibit many substances that cause inflammation and also inhibit the synthesis of pro-inflammatory enzymes.
Onset of Action:
- Onset: varies
- Peak: 4-8 days
- Duration: 1-5 weeks (IM)
- Half-Life: 3.5 hours
Serve anaphylaxis, asthma, or COPD, and Urticaria
No major contraindications in the acute management of serve anaphylaxis
Only one dose pre-hospital should be given, Long term therapy can cause GI bleeding, prolonged wound healing, and suppression of adrenocortical steroids
- Abdominal distention
- Fluid retention
Serve anaphylaxis- 125-250 mg administered IV. Can be given IM but IV is preferred in EMS
Pre-hospital is one dose 125-250 mg
Routes of Administration
Prefilled syringes or vials with 250mg OR 125mg