The method by which drug is made available to the body.
1.) Aerosol is the most common route for drug administration to the pulmonary patient.
2.) Common devices used to deliver inhaled aerosols are the MDI, SVN, And dry powder inhaler.
3.) Advantages of inhaled aerosols:
- Can use smaller doses as compared to the systemic route.
- Onset of drug is rapid
- Delivery is targeted to the organ requiring treatment.
- Less systemic side effect.
The pharmakinetic phase
Describes the time course and deposition of a drug in teh body based on its absoprtion, distrubution, metabolism, and elimination.
The pharmacodynamic phase
Describes the mechanism of drug action by which a drug molecule causes its effects in the body.
Drug effects are caused by combination of a drug with a matching receptor.
What are the airway receptors in teh lung? and what are the neurotransmitters for each receptor?
Sympathetic (Adrenergic) - The neurotransmitter in the sympathetic is norepineprine (epineprine)
Parasympathetic (Cholinergic) the neurotransmitter in the parasympathetic is Acetylcholine.
Indication for short acting agents
Short acting b2 agonist such as albuterol and levelbuterol (Xopenex) are indicated for relief of acute reversable airflow obstruction in asthma or other obstructive airway diseases.
Indication for long acting agents
Long acting agents such as salmetrol, formoterol, or arformetrol are indicated for maintenance broncodilation and control of broncospasm and nonctumal symptoms in asthma or other obstructive diseases like COPD.
To reduce airway swelling after extubation or w/ acute upper airway inflammation from CROUP, epiglottitis, or bronchitis.
Often used either by inhaled aerosol or by direct lung instillation for its strong a-adrenergic vasocontricting effect.
Causes vasoconstriction and a vaspopressor drug (Increase in blood pressure)