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When are NMD's used?
- When predictable, profound relaxation is needed
- Management of vent
- Total muscle relaxation isn't essential
What types of specific Sx's are NMB drugs used for?
- Deep laparotomy
- Orthopedic Sx
- Inhibit Scratch Rflx (Ear sx)
3 Prerequ's to use of M relaxant drugs:
- Must be unconscious
- Adequate Analgesia
- Support Ventilation
Disadvantages of of NM blockade (6):
- Controlled Vent, required
- Hard to monitor anesthesia and analgesia
- No motor response
- Complexity of blockade monitering
- many factors influence drug kinetics and dynamics
- Recurarisation Post-Op
What is the Endogenous Agonist?
___ is released from nerve ending in response to stimulus, crosses the synaptic cleft and binds to the post-junctional _____ receptor on the surface of the muscle cell.
Three primary types of drugs used for muscle relaxation:
- Depolarizing Muscle Relaxants
- Non-Depolarizing Muscle Relaxants
- Centrally Acting M Relaxants
- Drugs with muscle relaxing properties
Depolarizing M Relaxants include:
Non-Depolarizing M Relaxants include:
Centrally Acting M Relaxants include:
Drugs with muscle relaxing properties include:
- Alpha 2 Agonists
The ideal muscle relaxant (5):
- Rapid Onset
- Intermediate Duration
- Does't block Ganglion
- No Antimuscarinic Side Effects
- No Histamine release
Neuromuscular blocking drugs used in Dogs:
Neuromuscular blocking drugs used in Horses:
What animals are very sensitive to Neuromuscular Blocking Drugs?
cholinergic receptros at the