Pharm, IV NMB

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  1. When are NMD's used?
    • When predictable, profound relaxation is needed
    • Management of vent
    • Total muscle relaxation isn't essential
  2. What types of specific Sx's are NMB drugs used for?
    • Intraocular
    • Intracranial
    • Deep laparotomy
    • Orthopedic Sx
    • Inhibit Scratch Rflx (Ear sx)
  3. 3 Prerequ's to use of M relaxant drugs:
    • Must be unconscious
    • Adequate Analgesia
    • Support Ventilation
  4. Disadvantages of of NM blockade (6):
    • Controlled Vent, required
    • Hard to monitor anesthesia and analgesia
    • No motor response
    • Complexity of blockade monitering
    • many factors influence drug kinetics and dynamics
    • Recurarisation Post-Op
  5. What is the Endogenous Agonist?
    ACh
  6. ___ is released from nerve ending in response to stimulus, crosses the synaptic cleft and binds to the post-junctional _____ receptor on the surface of the muscle cell.
    • ACh
    • N1 Nicotinic
  7. Three primary types of drugs used for muscle relaxation:
    • Depolarizing Muscle Relaxants
    • Non-Depolarizing Muscle Relaxants
    • Centrally Acting M Relaxants
    • Drugs with muscle relaxing properties
  8. Depolarizing M Relaxants include:
    Succinylcholine
  9. Non-Depolarizing M Relaxants include:
    • Vecuronium
    • Atracurium
  10. Centrally Acting M Relaxants include:
    Guafenesin
  11. Drugs with muscle relaxing properties include:
    • Benzodiazapines
    • Alpha 2 Agonists
  12. The ideal muscle relaxant (5):
    • Non-Depolarizing
    • Rapid Onset
    • Intermediate Duration
    • Does't block Ganglion
    • No Antimuscarinic Side Effects
    • No Histamine release
  13. Neuromuscular blocking drugs used in Dogs:
    • Vecuronium
    • Rocuronium
    • Atracurium
    • Mivacurium
  14. Neuromuscular blocking drugs used in Horses:
    Atracurium
  15. What animals are very sensitive to Neuromuscular Blocking Drugs?
    Sheep
  16. cholinergic receptros at the
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Pharm, IV NMB
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Pharm, IV NMB
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