Ochem-CH21-COOHs

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Author:
lukemlj
ID:
75603
Filename:
Ochem-CH21-COOHs
Updated:
2011-04-25 07:18:03
Tags:
Ochem CH21 carboxylic acid derivatives
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Ochem-CH21- carboxylic acid derivatives
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  1. Acyl phosphate
  2. Nucleophilic Acyl Substitution Reaction
  3. Nomenclature
  4. An Sn2 reaction occurs in how many steps? A nucleophilic acyl substitution occurs in how many steps?
    One. Two.
  5. Describe the mechanism for an Sn2 reaction.
    Describe the mechanism for a nucleophilic acyl substitution.
    • Backside displacement of the leaving group.
    • Tetrahedral intermediate.
  6. In a nucleophilic acyl substitution reaction, ___ carbonyl groups are more reactive.
    unhindered
  7. In a nucleophilic acyl substitution reaction, ___ acyl compounds are more reactive.
    strongly polarized
  8. List the order of reactivty for acid chlorides, amides, esters, thioesters, and acid anhydrides.
    Acid chloride, acid anhydride, thioester, ester, amide.
  9. Hydrolysis
    Water to carboxylic acid
  10. Alcoholysis
    alcohol to ester
  11. Aminolysis
    ammonia or ari amine to amide
  12. Reduction
    Reaction with hydride reducing agent to aldehyde or alcohol
  13. Grignard Reaction
    Reaction with an organometallic reagent to a ketone or an alcohol
  14. + SO2 + HCl
  15. What are the most common carboxylic acid derivatives in the lab?
    acid halides, acid anyhydrides, esters, and amides
  16. What are the most common carboxylic acid derivatives in biological molecules?
    thioesters and acyl phosphates
  17. What reaction dominates carboxylic acid derivatives?
    nucleophilic acyl substitution
  18. What are examples of step-growth polymers?
    polyamides and polyesters
  19. How are polyamides formed?
    Reaction between a diacid and a diamine
  20. How are polyesters formed?
    Reaction between a diacid and a diol.

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