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Mechanism of action
Blocks cellular histamine receptors; decreases vasodilation; decreases motion sickness. Reverses extrapyramidal reactions
Symptomatic relief of allergies, allergic reactions, anaphylaxis, acute dystonic reactions (phenothiazines). Blood administration reactions, used for motion sickness, hay fever.
Asthma, glaucoma, pregnancy, hypertension, narrow angle glaucoma, infants pts. taking monoamine oxidase inhibitors (MAOIs).
Sedation, hypotension seizures, visual disturbances, vomiting, urinary retention, palpitations, arrhythmias, dry mouth and throat, and dparadoxical CNS excitation in children.
Potentiates effects of alcohol and other anticholinergics, may inhibit corticosteroid activity; MAOIs prolong anticholinergic effects of diphenhydramine.
- Tablets: 25, 50mg
- Capsules: 25, 50 mg
- Prefilled syringes: 50 or 100 mg vials (IV or IM)
- Elixer: 12.5 mg/5mL
Dosage and administration
- Adult: 25-50 mg IM or IV or PO.
- Pediatric: 1-2 mg/kg IV, IO slowly or IM
- if given PO: 5 mg/kg/24hrs.
Duration of action
- Onset: 15-30 minutes
- Peak effect: 1 hour
- Duration: 3-12 hours
Not used in infants or in pregnancy: category B. If used in anaphylaxis, will be in conjunction with epinephrine, corticosteroids.