DRUG MECHANISMS FINAL

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medic11
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76087
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DRUG MECHANISMS FINAL
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2011-03-29 21:31:37
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DRUG MECHANISMS FINAL
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Drug Mechanisms 3/29/11
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  1. What is the mechanism for albuterol?
    Selective beta2-adrenergic bronchodilator
  2. The mechanism of action of ipratropium is ____ ____.
    Anticholinergic Bronchodilator
  3. Amiodarone works by doing what?
    Prolonging the duration of the action potential & refrac period & relaxes smooth muscles
  4. ASA acts by:
    • Inhibiting agents causing inflammation, pain & fever
    • Inhibits platelet aggregation
  5. Atropine act by blocking the ____ ____ system specifically ___ effects on HR.
    • Parasympathetic NS
    • Vagal
  6. Calcium Chloride works by doing 2 things which are?
    • Increasing myocardial contractile force
    • Increasing ventricular automaticity
  7. Dexamethazone works by preventing:
    Accumulation of inflammation generating cells
  8. Dobutamine is a _____ & synthetic catecholamine that works by
    • Sympathomimetic
    • Agonizing beta cells increasing strength of cardiac contraction w/o changing rate
  9. Dopamine is a _____ & natural catecholamine that acts on the ____ NS to increase ____ & ____.
    • Sympathomimetic
    • Sympathetic NS
    • HR & BP
  10. Diphenhydramine works by:
    Blocking effect of histamine @ H1 receptor sites
  11. Diltiazem's mechanism is that it ____ ____ similar to ____.
    Slow CCB similar to verapamil
  12. Diazepam works by:
    enhancing the effects of GABA by binding to the benzo site on the GABAa receptor
  13. Epi acts by:
    Stimulating the sympathetic NS and binding to alpha & beta receptors
  14. Etomidate works by acting on ____ receptors containing ____ subunits.
    • GABAa receptors
    • beta 3
  15. Furosemide is a ____ ____ that works by doing what in the kidneys?
    • Loop Diuretic
    • Inhibiting Na reabsorption by the kidney
  16. Glucagon works by causing:
    The liver to convert stored glycogen into glucose
  17. Heparin acts by:
    Enhancing the effects of antithrombin III & blocking conversion of prothrombin to thrombin & fibrinogen to fibrin
  18. Isoproterenol stimulates the ____.
    Sympathetic NS increasing tropic properties
  19. Lidocaine is an antidysrhythmic that suppresses ____ & raises ____ ____ of the ____.
    • Automaticity
    • Stimulation Threshold
    • Ventricles
  20. Mag Sulfate is an electrolyte that acts as a ____, ____ & ____.
    • CCB
    • CNS depressant
    • Anticonvulsant
  21. Mannitol (aka ____) is an ____ ____ that works by:
    • Osmitrol
    • Osmotic Diuretic
    • Drawing H2O into intravascular space then causing diuresis
  22. Metoclopramide (aka ____) is a ____ ____ that causes:
    • Reglan
    • Dopamine Antagonist
    • Rapid Gastric emptying & desensitization of vomiting reflex
  23. Morphine Sulfate acts by:
    Binding w/mu opiod sites in the CNS
  24. Naloxone act by:
    Competitively antagonizing mu opioid receptors
  25. NTG acts by:
    Causing vasodilation decreasing BP & cardiac preload & increasing HR
  26. Phenytoin (aka ____) acts by:
    • Dilantin
    • Reducing spread of elec discharges in motor cortex & inhibits seizures
  27. Procainamide (aka____) acts by:
    • Pronestyl
    • Prolonging ventricular repolarization, slowing conduction & decreasing myocardial excitability
  28. Promethazine (aka____) is an _____ agent that:
    • Phenergan
    • Anticholinergic
    • Enhances effects of analgesics
  29. The mechanism of Terbutaline is ____ ____.
    Sympathetic Agonist
  30. Sodium Bicarb acts by providing:
    Vascular bicarbonate to assist the buffer system
  31. Thiamine acts by helping the body to:
    Convert glucose into energy
  32. Verapamil is a ____ that does what 3 things?
    • CCB
    • Slows AV conduction, suppresses reentry dysrhythmias, slows ventricular response
  33. Zofran is a selective blocking agent of the ____ ____ receptor type.
    Serotonin 5-HT3
  34. Albuterol, Advair and Singular mechanism are all what?
    Beta Agonists
  35. Aciphex, Prevacid, Nexium, Protonix are all used to treat what?
    GERD
  36. The angiotensin Antagonists on our list are (2)?
    • Diovan
    • Benicar
  37. The mechanism of Digoxin is ____ ____.
    Cardiac Glycoside
  38. Zyrtec and Allegra are both ____.
    Antihistimines
  39. Skelaxin, Soma, Cyclobenzaprine and baclofen are all ____ ____ ____.
    Skeletal muscle relaxants
  40. The 4 NSAIDs on our list are what?
    • Diclofenac
    • Mobic
    • Naproxen
    • Celebrex
  41. Toprol XL, Propranalol (inderal), Atenolol (Tenormen) are all ____ ____.
    Beta Blockers
  42. Clonidine (aka ____) has a mechanism of what?
    • Catepres
    • Alpha II agonist
  43. Cardizem, Verapamil, Norvasc all have the mechanism of ____.
    CCB
  44. Enalapril (aka ____), Lotrel, & Lisinipril (aka ____) have the mechanism of:
    • Vasotec
    • Prinivil
    • ACE inhibitor
  45. An ACE inhibitor functions by:
    Blocking the conversion of angiotensin I to angiotensin II therefore limiting the vasoconstrictive effects of angiotensin II
  46. The ACE in ACE inhibitor stands for what?
    Angiotensin converting enzyme
  47. ACE inhibitors are aka ____ ____.
    Angiotensin blockers
  48. CCB cause their effect by:
    Blocking voltage gated Ca channels in cardiac muscle & blood vessels decreasing intracellular Ca leading to reduction in muscle contraction
  49. Beta blockers cause their effects by:
    Inhibiting normal epi mediated sympathetic actions by causing neg chronotropic & inotropic effects
  50. Loop diuretics work by:
    Inhibiting reabsorption of Na in the ascending loop of henle leading to retention of water in the urine
  51. Thiazide diuretics work by:
    Inhibiting the Na-Cl symporter in the distal convoluted tubule causing H2O retention in the urine
  52. How does digitalis work as a diuretic?
    By increasing cardiac output & increasing circulation thru kidneys
  53. How do osmotic diuretics work?
    By being filtered into the glomerulus leading to an increase in osmolarity of the filtrate. To maintain osmotic balance H2O is retained in urine

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