DRUG MECHANISMS FINAL
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What is the mechanism for albuterol?
Selective beta2-adrenergic bronchodilator
The mechanism of action of ipratropium is ____ ____.
Amiodarone works by doing what?
Prolonging the duration of the action potential & refrac period & relaxes smooth muscles
ASA acts by:
- Inhibiting agents causing inflammation, pain & fever
- Inhibits platelet aggregation
Atropine act by blocking the ____ ____ system specifically ___ effects on HR.
Calcium Chloride works by doing 2 things which are?
- Increasing myocardial contractile force
- Increasing ventricular automaticity
Dexamethazone works by preventing:
Accumulation of inflammation generating cells
Dobutamine is a _____ & synthetic catecholamine that works by
- Agonizing beta cells increasing strength of cardiac contraction w/o changing rate
Dopamine is a _____ & natural catecholamine that acts on the ____ NS to increase ____ & ____.
- Sympathetic NS
- HR & BP
Diphenhydramine works by:
Blocking effect of histamine @ H1 receptor sites
Diltiazem's mechanism is that it ____ ____ similar to ____.
Slow CCB similar to verapamil
Diazepam works by:
enhancing the effects of GABA by binding to the benzo site on the GABAa receptor
Epi acts by:
Stimulating the sympathetic NS and binding to alpha & beta receptors
Etomidate works by acting on ____ receptors containing ____ subunits.
Furosemide is a ____ ____ that works by doing what in the kidneys?
- Loop Diuretic
- Inhibiting Na reabsorption by the kidney
Glucagon works by causing:
The liver to convert stored glycogen into glucose
Heparin acts by:
Enhancing the effects of antithrombin III & blocking conversion of prothrombin to thrombin & fibrinogen to fibrin
Isoproterenol stimulates the ____.
Sympathetic NS increasing tropic properties
Lidocaine is an antidysrhythmic that suppresses ____ & raises ____ ____ of the ____.
- Stimulation Threshold
Mag Sulfate is an electrolyte that acts as a ____, ____ & ____.
- CNS depressant
Mannitol (aka ____) is an ____ ____ that works by:
- Osmotic Diuretic
- Drawing H2O into intravascular space then causing diuresis
Metoclopramide (aka ____) is a ____ ____ that causes:
- Dopamine Antagonist
- Rapid Gastric emptying & desensitization of vomiting reflex
Morphine Sulfate acts by:
Binding w/mu opiod sites in the CNS
Naloxone act by:
Competitively antagonizing mu opioid receptors
NTG acts by:
Causing vasodilation decreasing BP & cardiac preload & increasing HR
Phenytoin (aka ____) acts by:
- Reducing spread of elec discharges in motor cortex & inhibits seizures
Procainamide (aka____) acts by:
- Prolonging ventricular repolarization, slowing conduction & decreasing myocardial excitability
Promethazine (aka____) is an _____ agent that:
- Enhances effects of analgesics
The mechanism of Terbutaline is ____ ____.
Sodium Bicarb acts by providing:
Vascular bicarbonate to assist the buffer system
Thiamine acts by helping the body to:
Convert glucose into energy
Verapamil is a ____ that does what 3 things?
- Slows AV conduction, suppresses reentry dysrhythmias, slows ventricular response
Zofran is a selective blocking agent of the ____ ____ receptor type.
Albuterol, Advair and Singular mechanism are all what?
Aciphex, Prevacid, Nexium, Protonix are all used to treat what?
The angiotensin Antagonists on our list are (2)?
The mechanism of Digoxin is ____ ____.
Zyrtec and Allegra are both ____.
Skelaxin, Soma, Cyclobenzaprine and baclofen are all ____ ____ ____.
Skeletal muscle relaxants
The 4 NSAIDs on our list are what?
Toprol XL, Propranalol (inderal), Atenolol (Tenormen) are all ____ ____.
Clonidine (aka ____) has a mechanism of what?
Cardizem, Verapamil, Norvasc all have the mechanism of ____.
Enalapril (aka ____), Lotrel, & Lisinipril (aka ____) have the mechanism of:
- ACE inhibitor
An ACE inhibitor functions by:
Blocking the conversion of angiotensin I to angiotensin II therefore limiting the vasoconstrictive effects of angiotensin II
The ACE in ACE inhibitor stands for what?
Angiotensin converting enzyme
ACE inhibitors are aka ____ ____.
CCB cause their effect by:
Blocking voltage gated Ca channels in cardiac muscle & blood vessels decreasing intracellular Ca leading to reduction in muscle contraction
Beta blockers cause their effects by:
Inhibiting normal epi mediated sympathetic actions by causing neg chronotropic & inotropic effects
Loop diuretics work by:
Inhibiting reabsorption of Na in the ascending loop of henle leading to retention of water in the urine
Thiazide diuretics work by:
Inhibiting the Na-Cl symporter in the distal convoluted tubule causing H2O retention in the urine
How does digitalis work as a diuretic?
By increasing cardiac output & increasing circulation thru kidneys
How do osmotic diuretics work?
By being filtered into the glomerulus leading to an increase in osmolarity of the filtrate. To maintain osmotic balance H2O is retained in urine
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