Hyperlipidemia Drugs

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Author:
eschott
ID:
76091
Filename:
Hyperlipidemia Drugs
Updated:
2011-03-29 21:41:57
Tags:
Pharm Drugs
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  1. What is the mechanism for Cholestyramine?
    Bind bile acids in GI = low absorption, increased production (take just before meals)
  2. What is the mechanism for Colesevelam?
    Bind bile acids in GI = low absorption, increased production (take just before meals)
  3. What is the mechanism for Colestipol?
    Bind bile acids in GI = low absorption, increased production (take just before meals)
  4. What is the mechanism for Lovastatin?
    HMG-CoA reductase inhibition (competitive)
  5. What is the mechanism for Simvastatin?
    HMG-CoA reductase inhibition (competitive)
  6. What is the mechanism for Atorvastatin?
    HMG-CoA reductase inhibition (competitive)
  7. What is the mechanism for Rosuvastatin?
    HMG-CoA reductase inhibition (competitive)
  8. What is the mechanism for Pravastatin?
    HMG-CoA reductase inhibition (competitive)
  9. What is the mechanism for Fluvastatin?
    HMG-CoA reductase inhibition (competitive)
  10. What is the mechanism for Ezetimibe?
    Decreased absorption of Cholesterol at brush border
  11. What is the mechanism for Niacin?
    Decreased VDL synthesis
  12. What is the mechanism for Laropiprant?
    Prostaglandin D-2 antagonist
  13. What is the mechanism for Gemfibrozil?
    Insulin-like PPARa induction of genes resulting in decreased VDL synthesis and increased VDL catabolism (up HDL by increasing apoA-1/2)
  14. What is the mechanism for Fenofibrate?
    Insulin-like PPARa induction of genes resulting in decreased VDL synthesis and increased VDL catabolism (up HDL by increasing apoA-1/2)
  15. What is the mechanism for Fish Oil?
    Suppresses VLDL production
  16. What are indications for Bile Acid Binding Resins?
    Heterozygous familial hypercholesterolemia, combined hyperlipidemia
  17. What are indications for Statins?
    Familial hypercholesterolemia, combined hyperlipidemia
  18. What are indications for Niacin?
    Heterozygous familial hypercholesterolemia, combined hyperlipidemia, dysbetalipoproteinemia, etc.
  19. What are indications for Laropiprant?
    Flushing induced by Niacin
  20. What are indications for Fibrates?
    Moderate & severe Familial Hypertriglyceridemia, others
  21. What are indications for Fish Oil?
    All patients (?)
  22. What are side effects of bile acid binding resins?
    Constipation, bloating, gallstones (rare) and steatorrhea (rare) (colesevelam is best tolerated)
  23. What are side effects of Statins?
    Hepatotoxicity, myopathy, rhabdomyolysis in high doses, NEVER given to pregnant women
  24. What are side effects of Niacin?
    Flushing TX
  25. What are side effects of Fibrates?
    (Rare) skin rash, GI Sx, myopathy - rhabdo when combined with statins, anemia, Gall stones
  26. What are drug interactions of bile acid binding resins?
    Interferes with absorption: digitalis, thiazides, beta blockers, warfarin, fat soluble vitamins (K)
  27. What are drug interactions of Lovastatin?
    Grapefruit/Verapamil inhibit CYP3A4 = increases conc of statins
  28. What are drug interactions of Simvastatin?
    Grapefruit/Verapamil inhibit CYP3A4 = increases conc of statins
  29. What are drug interactions of Atorvastatin?
    Grapefruit/Verapamil inhibit CYP3A4 = increases conc of statins
  30. What are drug interactions of Rosuvastatin?
    No CYP3A4 interactions
  31. What are drug interactions of Pravastatin?
    No CYP3A4 interactions
  32. What are drug interactions of Fluvastatin?
    No CYP3A4 interactions
  33. What are drug interactions of Fibrates?
    Potentiates coumarin (warfarin), indanedione anticoagulants

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