Card Set Information
What are possible solutions/treatments for hypersecretion of an endocrine gland?
Removal of tissue by surgery, irradiation followed with replacement therapy
Administration of drugs./hormones that suppress synthesis and secretion of the hormone
What are the 3 chemical classes of hormones?
: adrenal, sex, claciferols, vitamins
: hypothalamic releasing factors, pituitary hormoines, insulin/glucagon/calcitonin/oxytocin/vasopressin/relaxin/GI hormones
: dopamine, epi, thyroid hormones
What is the administration route for the differet types of hormones?
: peptide and catecholamens
: synthetic steroids and thyroid hormones
What is the system of simple negative feedback control?
Hormone secreted from endocrine gland
Hormone travels to target cell via blood
Increased level of substrate in blood inhibits release of hormone from endocrine gland
What are examples of simple negative feeback control?
What are examples of complex endocrine control system?
GnRH/LH & FH/estrogen & progesterone
What are the effects of GH on normal tissue?
Positive nitrogen balance
Protein synthesis enhanced
AA transport into tissues
What are the effects of GH in DM?
Hyperglycemia and ketosis
What is Somatomedin C?
Insulin-like Growth Factor 1
Stimulated by GH to stimulate chondrocytes to form cartilage and matrix
How is GH release regulated?
GHRH (positive effect) or somatostatin/SST (negative effect) released from neurons in hypothalamus
What is the signal pathway of GHRH in the pituitary?
Gs (stimulatory) transducer
Increase Adenylyl Cyclase
Activate protein kinase A
Phosphorylation of proteins
What is the signal pathway of SST in the pituitary?
Decrease Adenylyl Cyclase
Inhibit GH relase
Inhibit GH release
What are factors the stimulate GH release?
What is Sermorelin?
Synthetic GHRH for treatment of hypopituitary dwarfism from GHRH deficiency at hypothalamic level
What is Mecasermin?
Synthetic IGF-1 protein that binds to and increases t
of human IGF-1
Used in Laron Syndrome with defective GH receptors
What is the treatment of Hypopituitary Dwarfism?
GH SQ/IM thoughout childhood
Dex hormones at puberty
What's the effect of glucocorticoids on GH?
Decrease GH release
What's the treatment of Hyperpituitary Dwarfism?
Defective GH receptros can't stimulate IGF-1
Mescasermin therapy increases IGF-1 t
What's the risk brough by use of GH for cosmetic purposes?
Carpal Tunnel Syndrome
Paradoxocal inhibition of GH release in pts with Acromegally
Best in pts with
GH & Prolacitn
SST synthetic analog with longer t
IM once a month for Acromegally
: nausea, diarrhea, abdominal pain
Pancreatic cholera (inhibits VIP secretion)
Binds to GH receptors to decrease IGF-1 production
: site reactions, nausea, diarrhea, chaest pain, flu syndrome
What regulates Prolactin release?
Dopamine from hypothalamus (Inhibits synthesis and release)
TRH (enhncaese prolactin release via Ca
What factors stimulate prolactin secretion?
Preganancy (sucking, stress, hypoglycemia, estrogen)
What's the treatment for hyperprolactinemia?
Bromocriptine (dopamine agonist)
: galactorreha, amenorrhea, vision impairment