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H-bond to 30S subunit (Mg): interfere with communication between rRNA & tRNA
Prevent small and large subunit to bind (H-bond)
Binds to Flipase
Binds Mg and disrupt membrane -> essential biochemicals leak out
Binds to bacterial membrane Ca and depolarize
Binds to PTC and prevent peptide formation
Mimics PABA and prevent formation of folic acid
Inhibit Topoisomerase IV nd DNA Gyrase
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