epinephrine_hcl.txt

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Author:
papeirce
ID:
76488
Filename:
epinephrine_hcl.txt
Updated:
2011-03-31 17:22:17
Tags:
paramedic medications drugs prehospital epinephrine hcl
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Description:
Prehospital Medication Flashcards for Paramedic school - Massachusetts and Rhode Island
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  1. Epinephrine HCL

    Trade Name
    Adrenaline
  2. Epinephrine HCL

    Class
    Sympathomimetic
  3. Epinephrine HCL

    Mechanism of Action
    • Direct acting alpha and beta agonist
    • Alpha: bronchial, cutaneous, renal and visceral arteriolar vasoconstriction
    • Beta 1: positive inotropic and chronotropic actions, increases automaticity
    • Beta 2: bronchial smooth muscle relaxation and dilation of skeletal vasculature
    • Blocks histamine release
  4. Epinephrine HCL

    Indications
    • Cardiac arrest
    • Asystole/PEA
    • VF/Pulseless VT
    • Severe Bronchospasm
    • Asthma
    • Bronchiolitis
    • Anaphylaxis
    • Bradycardia (Infants/Children)
  5. Epinephrine HCL

    Contraindications
    • Hypertension
    • Hypothermia
    • Pulmonary edema
    • Coronary insufficiency
    • Hypovolemic shock
  6. Epinephrine HCL

    Adverse Reactions
    • Hypertension
    • Dysrhythmias
    • Pulmonary edema
    • Anxiety
    • Psychomotor agitation
    • Nausea
    • Angina
    • Headache
    • Restlessness
  7. Epinephrine HCL

    Drug Interactions
    • Potentiates other sympathomimetics
    • Deactivated by alkaline solutions
    • MAOIs may potentiate effects of epinephrine
  8. Epineprine HCL

    How Supplied
    • 0.1 mg/ml (1:1000) ampules
    • 0.1 mg/ml (1:1000) vials (30mg multidose)
    • 0.1 mg/ml (1:10,000) prefilled syringes 1mg/10ml
    • Auto-injectors:
    • EpiPen®: 0.3 mg (1:1000, 0.3ml)
    • EpiPen Jr®: 0.15mg (1:2000, 0.3ml)
  9. Epinephrine HCL

    Dosage and Administration
    Adult
    • Bronchospasm/Respiratory Distress/Allergic Reactions/Anaphylaxis:
    • 0.15 -0.3 mg (0.15 -0.3 ml 1:1000) IM (Auto-Injector in MA)
    • Cardiac: (Asystole/PEA, Ventricular Fibrillation/Ventricular Tachycardia): 1 mg (1:10,000) q. 3-5 minutes IV/IO if IV/IO access is unavailable
    • Endotracheal: 2.0-5.0 mg (1:1,000) every 3-5 minutes in 10ml NS
    • Bradycardia:
    • Infusion mix 1 mg 1:1000 in 250ml NS yield 4 mcg/ml run @ 2-10 mcg/min
  10. Epinephrine HCL

    Dosage and Administration
    Pediatric
    • Bronchospasm/Respiratory Distress/Allergic Reactions/Anaphylaxis: 0.15 -0.3 mg (0.15 mg-0.3 mg 1:1000) IM (Auto-Injector in MA)
    • Croup: 5ml (1:1000) via nebulizer over 5-15 minutes
    • Cardiac: (Asystole/PEA, Ventricular Fibrillation/Ventricular Tachycardia):
    • Standard initial dose: 0.01 mg/kg (1:10,000, 0.1mL/kg) q. 3-5 min. IV/IO
    • Bradycardia:
    • IV/IO: Standard initial dose: 0.01 mg/kg (1:10,000, 0.1mL/kg) maximum single dose of 0.5 mg.
    • Infusion mix 1 mg 1:1000 in 250ml NS yield 4 mcg/ml run @ 0.1-1.0 mcg/kg/min
  11. Epinephrine HCL

    Duration of Action
    • Onset: Immediate
    • Peak Effects: Minutes
    • Duration: Several minutes
  12. Epinephrine HCL

    Special Considerations
    Pregnancy safety: Category C

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