Anti-hypertensive drugs.txt

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Author:
Salva
ID:
76524
Filename:
Anti-hypertensive drugs.txt
Updated:
2011-04-03 04:45:38
Tags:
Pharma
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Description:
Anti-hypertensive drugs
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  1. What classes?
    • Thiazide diuretics
    • Beta blockers
    • Vasodilators (Ca channel blocker & alpha 1 receptor blockers)
    • Drugs affecting renin-angiotensin system (ACE & Angiotensin II inhibitors)
  2. Chlorothiazide
    • Thiazide diuretc
    • Inhibit Na & Cl absorbtion in distal convoluted tubule
    • Mild-moderate HyT
    • Increase loss of K
  3. Propanolol
    • Beta-blocker
    • Prevent beta receptors to naturally in crease Ht rate & force of contraction
    • Mild-moderate HyT (no asthma!)
    • Ht failure, brochospasm
  4. Atenolol
    • Beta-blocker
    • Prevent beta receptors to naturally increase Ht rate & force of contraction
    • Mild-moderate HyT (no asthma!)
    • Ht failure, brochospasm
  5. Nifedipine
    • Vasodilator - calcium channel blocker
    • Act on Ca channels to block contractions of cardiac + smooth muscle and dilate vessels
    • HyT (used in comb with beta-blockers)
    • Dizziness, nausea, drop in BP
  6. Verapamil
    • Vasodilator - calcium channel blocker
    • Act on Ca channels to block contractions of cardia + smooth muscle and dilate vessels
    • HyT (not used in comb with beta-blockers)
    • Nausea, fever, sore throat, heachache
  7. Prazosin
    • Vasodilator - alpha 1 receptor blocker
    • Inhibit alpha receptor on smooth muscle through blocking constrictor effect of noradrenline/adrenalie (catecholamines
    • HyT (in comb with diuretics)
    • Postural hypotension
  8. Captopril (original)
    • ACE inhibitor (act on ACE to modify activity of angiotensin II)
    • Blocks ACE to vasoconstrict, remodel vessels, release aldosterone, retain Na
    • Mild-moderate HyT, Ht failure
    • Dry cough, headache, fatigue
  9. Lisinopril
    • ACE inhibitor (act on ACE to modify activity of angiotensin II)
    • Blocks ACE to vasoconstrict, remodel vessels, release aldosterone, retain Na
    • Mild-moderate HyT, Ht failure
    • Dry cough, headache, fatigue
  10. Irbesartan
    • Angiotensin II receptor inhibitor (act on angiotensin II to block binding with AT1 receptors)
    • HyT
    • Hypotension, tachycardia

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