Synapse

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Author:
pretty4Jesus
ID:
76614
Filename:
Synapse
Updated:
2011-04-01 13:49:26
Tags:
Neuroscience Block
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Description:
synapses
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  1. Calcium
    Rise in Ca both nec and suff for NT release
  2. SV proteins
    • SYNAPTOMTAGMIN (Ca sensor)
    • synapsin
    • synaptobrevin (SNARE)
  3. Presynaptic membrane prot
    • Ca channels (ca influx)
    • SNAP-25 (SNARE)
    • syntaxin (SNARE)
  4. SV priming and fusion
    • components of the SNAREs
    • syntaxin, synaptobrevin, SNAP-25

    *Botulism- cleane SNARE< impairment of NT release
  5. SV fussion
    Ca-synaptotagmin-triggeres fussion
  6. IonotrophicR
    • ligand-gated R, fast (ms)
    • cation selective-excit. inputs
    • chloride selective- inhibitory inputs (GABAA & glycineR)

    pentamer (5 subunit); each 4 trans
  7. MetabotrophicR
    • slow (ms-min)
    • single 7 transmemb domain pept

    single polypept; each 7 trans
  8. Excit
    Erev>thresh
  9. Inhib
    Erev<thresh
  10. dense cores
    • Ach and aa: small clear v: 40-60nm diam
    • Biogenic amines: small dense-core v: 40-60 or larger
    • Neuropetides: large dense-core v: 90-250nm
  11. Reuse
    small-molecule NTs: specific uptake transporters, recyles **except Ach- gegraded in cleft

    NPT- proteolytically degraded outside cell
  12. nAChR
    *myesthenia gravis- autoimmune that affect nAChR.. weakness.
  13. NMDAR
    • "coincidence R"
    • need bindin of glutamate & depol
  14. long-range attraction/repulsion
    netrin (can be long-range retractant as well dep on Rs!)
  15. short range repulsion
    ephrins in eye
  16. short range attraction
    • fasciculation
    • 1. follow second
    • 2. pioneer ns
    • 3, regeneration (in PNS. CNS has lots of short range repulsive signals)

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