In the formation of uric acid, an amino group is removed from AMP to produce _____ by AMP deaminase, or from adenosine to produce _________ (hypoxanthine-ribose) by adenosine deaminase. IMP and GMP are then converted into their nucleoside forms, ________ and ________, by the action of 5'-nucleotidase. Purine nucleoside phosphorylase then converts inosine and guanine to their respective purine bases, __________ and ____________. Guanine is deaminated to form _________. Hypoxanthine is oxidized by xanthine oxidase to form __________, which is further oxidized by xanthine oxidase to form uric acid.
- Inosine & Guanine
- Hypoxanthine & Guanine