Study Guide Chapters 10, 11 Pharmacology

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tswhite
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76841
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Study Guide Chapters 10, 11 Pharmacology
Updated:
2011-04-02 21:12:40
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Surfactant Agents Corticosteroids
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Part 3 of 3 for test on chapters 6-11
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  1. Another name for surface-active agents is:
    A. mucolytic
    B. brochodilator
    C. antibiotic
    D. detergent
    D. detergent
    (this multiple choice question has been scrambled)
  2. For an alveolus, LaPlace's Law is written as:
    A. pressure = (4 x surface tension)/radius
    B. dyn/cm
    C. pressure = surface tension/radius
    D. pressure = (2 x surface tension)/radius
    D. pressure = (2 x surface tension)/radius
    (this multiple choice question has been scrambled)
  3. Lack of pulmonary surfactant in respiratory distress syndrome of the newborn results in:
    A. incr compliance
    B. no effect on surface tension
    C. high surface tension
    D. low surface tension
    C. high surface tension
    (this multiple choice question has been scrambled)
  4. The term used to describe surfactant produced outside of the patient's body is:
    A. endogenous
    B. exogenous
    C. natural
    D. bovine
    B. exogenous
    (this multiple choice question has been scrambled)
  5. Surfactant is produced by:
    A. alveolar type I cells
    B. alveolar type II cells
    C. goblet cells
    D. macrophages
    B. alveolar type II cells
    (this multiple choice question has been scrambled)
  6. Surfactant is composed primarily of :
    A. phospholipids
    B. water
    C. proteins
    D. neutral lipds
    A. phospholipids
    (this multiple choice question has been scrambled)
  7. Surfactant is stored in:
    A. lamellar bodies
    B. alveoli
    C. type II alveolar cells
    D. lipids
    A. lamellar bodies
    (this multiple choice question has been scrambled)
  8. The major stimulus for secretion of surfactant into the alveolus is:
    A. infection
    B. cough
    C. lung inflation
    D. lung deflation
    C. lung inflation
    (this multiple choice question has been scrambled)
  9. Which of the following are natural surfactant preparations?
    I. surfaxin
    II. curosurf
    III. survanta
    IV. infasurf

    A. II and III only
    B. I and II only
    C. II, III, and IV
    D. III and IV only
    C. II, III, and IV
    (this multiple choice question has been scrambled)
  10. Natural surfactant is obtained by all of the following methods except:
    A. amniotic fluid extraction
    B. human alveolar wash
    C. in vitro preparation
    D. animal alveolar wash
    C. in vitro preparation
    (this multiple choice question has been scrambled)
  11. Which of the following are approved indications for surfactant therapy?
    I. prophylaxis in very low birth wight (<1250 g infants)
    II. prophylaxis in infants of higher birth weight (>1250 g) but with immature lungs
    III. rescue treatment in infants with respiratory distress syndrome
    IV. acute respiratory distress syndrome in the adult

    A. I, II,III, and IV
    B. I and III only
    C. I and II only
    D. I, II, and III only
    D. I, II, and III only
    (this multiple choice question has been scrambled)
  12. Which of the following are currently used methods for delivering surfactant into infants?
    I. instillation through side-port catheter
    II. instillation through catheter
    III. nebulization
    IV. ECMO

    A. I and III only
    B. I and II only
    C. I, II, and III oly
    D. I, II, III and IV only
    B. I and II only
    (this multiple choice question has been scrambled)
  13. You are in the room of a 36-week gestationa baby that has just been born. The newborn weighs 2200 g. On assessment you find the baby has good color, no retractions, no nasal flaring, a RR of 25, a HR of 110, and a pulse-ox of 96% on room air. Which of the following would you choose?
    A. calfactant
    B. beractant
    C. albuterol
    D. no indication for therapy at this time
    D. no indication for therapy at this time
    (this multiple choice question has been scrambled)
  14. A newborn baby weighing 1000 g exhibits symptoms of RDS, including poor color, suprasternal retractions, nasal flaring, and desaturations. The therapist should recommend:
    A. dornase alfa
    B. salmeterol
    C. ipratropium bromide
    D. poractant alfa
    D. poractant alfa
    (this multiple choice question has been scrambled)
  15. All the following are considered natural surfactants except:
    A. poractant alfa
    B. calfactant
    C. dornase alfa
    D. beractant
    C. dornase alfa
    (this multiple choice question has been scrambled)
  16. The usual method of administering exogenous surfactant to babies is:
    A. rectal suppository
    B. nebulization
    C. intravenously
    D. direct instillation to the airway
    D. direct instillation to the airway
    (this multiple choice question has been scrambled)
  17. Which of the following is considered the mode of action for surfactant?
    A. to emulsify lung secretions
    B. to relax bronchial smooth muscle
    C. to replace missing surfactant
    D. to accelerate lung maturity
    C. to replace missing surfactant
    (this multiple choice question has been scrambled)
  18. All the following are hazards or complications of exogenous surfactants except:
    A. tachycardia
    B. pulmonary insult via barotrauma
    C. overoxygenation
    D. airway occlusion
    A. tachycardia
    (this multiple choice question has been scrambled)
  19. You are in the room of a 26-week gestational baby that has just been born. The newborn wieghs 1200 g. On assessment you find the baby has poor color, substernal retractions, nasal flaring, RR of 45, HR of 140. You note that the baby is difficult to bag. Which of the following agents wyould you recommend?
    A. albuterol
    B. solu-medrol
    C. cromolyn sodium
    D. beractant
    D. beractant
    (this multiple choice question has been scrambled)
  20. A significant side effect of corticosteroid use is inhibition of:
    A. HPA axis
    B. IgE
    C. SRS-A
    D. PGE
    A. HPA axis
    (this multiple choice question has been scrambled)
  21. All of the following are types of corticosteroids produced in the adrenal cortex except:
    A. mineralcorticoids
    B. corticotropin-releasing factor
    C. sex hormones
    D. glucocorticoids
    B. corticotropin-releasing factor
    (this multiple choice question has been scrambled)
  22. Corticosteroids normally produced by the body are known as:
    A. endogenous
    B. intrinsic
    C. extrinsic
    D. exongenous
    A. endogenous
    (this multiple choice question has been scrambled)
  23. Which of the following are examples of steroids available for inhalation?
    I. flunisolide
    II. azmacort
    III. QVAR
    IV. interleukin

    A. I, II, III, and IV only
    B. II and III only
    C. I, II, and III only
    D. I and II only
    C. I, II, and III only
    (this multiple choice question has been scrambled)
  24. The rise and fall of levels of glucocorticoids in the body follows what kind of rhythm?
    A. circadian
    B. monthly
    C. weekly
    D. no set rhythm
    A. circadian
    (this multiple choice question has been scrambled)
  25. The inflammatory process includes which of the following activities?
    I. mediator cascade
    II. incr vasular permeability
    III. leukocytic infiltration
    IV. phagocytosis

    A. II and III only
    B. I, II, III, and IV
    C. I and II only
    D. I, II, and IV only
    B. I, II, III, and IV
    (this multiple choice question has been scrambled)
  26. The major cells responsible for an inflammatory response in asthma are:
    A. basophils and SRS-A
    B. mast cells and eosinophils
    C. T lymphocytes and macrophages
    D. macrophages and mast cells
    B. mast cells and eosinophils
    (this multiple choice question has been scrambled)
  27. The early phase of an astmatic reaction occurs during what time frame?
    A. 15 min to an hour
    B. 2 to 4 hours
    C. 6 to 8 hours
    D. 24 hours
    A. 15 min to an hour
    (this multiple choice question has been scrambled)
  28. The product combining an inhaled steroid and a bronchodilator is:
    A. flovent
    B. QVAR
    C. azmacort
    D. advair
    D. advair
    (this multiple choice question has been scrambled)
  29. Side effects of systemic steroid treatment include which of the following?
    I. HPA suppression
    II. cough
    III. dysphonia
    IV. psychiatric reactions

    A. II and III only
    B. I, II, and III only
    C. I and IV only
    D. I, II, III and IV
    C. I and IV only
    (this multiple choice question has been scrambled)
  30. Side effects of aerosolized steroid use include all of the following except:
    A. cough
    B. osteoporosis
    C. dysphonia
    D. oral thrush
    B. osteoporosis
    (this multiple choice question has been scrambled)
  31. In COPD, the primary inflammatory cells are:
    A. T lymphocytes
    B. macrophages
    C. neutrophils
    D. eosinophils
    C. neutrophils
    (this multiple choice question has been scrambled)
  32. The steroids responsible for secondary male sex characteristics are known as:
    A. androgenic
    B. exogenous
    C. mineralocorticoids
    D. glucocorticoids
    A. androgenic
    (this multiple choice question has been scrambled)
  33. Corticosteroids are used with asthmastics and COPD patients to achieve which effect?
    A. breakdown of secretions
    B. immunosuppression
    C. antiinflammatory
    D. reduced surface tension
    C. antiinflammatory
    (this multiple choice question has been scrambled)
  34. Use of oral steroids for long periods of time can cause:
    A. incr ACTH levels
    B. incr adrenal cortex activity
    C. HPA suppression
    D. bronchospasm
    C. HPA suppression
    (this multiple choice question has been scrambled)
  35. In what dosage form is/are corticosteroids available for use in the US?
    a. DPI
    b. MDI
    c. nebulizer solution
    d. all of the above
    d. all of the above
  36. Which of the following is a common side effect of inhaled corticosteroids?
    A. oral candidiasis
    B. immunosuppression
    C. tachycardia
    D. bradycardia
    A. oral candidiasis
    (this multiple choice question has been scrambled)
  37. A patient has been taking oral prednisone for 1 week following a severe episode of asthma. The physician decides to switch the patient to aerosolized beclomethasone (QVAR). What is the best way to accomplish this?
    A. begin the aerosol and begin to gradually taper off the oral dose
    B. keep the patient on the full-strength oral dose and add the aerosol as well as for stronger results
    C. you cannot stop oral steroids once they are begun
    D. simply stop the oral drug and begin the aerosol
    A. begin the aerosol and begin to gradually taper off the oral dose
    (this multiple choice question has been scrambled)
  38. A patient complains of oral thrush and hoarseness since she has been using fluticasone by MDI. The physician asks you to make a suggestion to help her without discontinuing the drug. You suggest:
    A. pause 5 minutes between puffs
    B. inhale with a higher inspiratory flow rate
    C. add a spacer and rinse the mouth after use
    D. switch to a DPI
    C. add a spacer and rinse the mouth after use
    (this multiple choice question has been scrambled)
  39. Use of systemic corticosteroids can cause all of the following, except:
    A. incr endogenous steroid production
    B. fluid retention
    C. HPA suppression
    D. incr WBC count
    A. incr endogenous steroid production
    (this multiple choice question has been scrambled)
  40. Your patient tells you that she is having chest tightness and wheezing four to six times per week, plus she wakes up with chest tightness and wheezing about once per week. She uses albuterol each time, with relief. She is taking no other medication, except her albuterol MDI. What other medication would you suggest be prescribed for her?
    A. oral tobramycin
    B. salmeterol MDI
    C. beclomethasone MDI
    D. pirbuterol MDI
    C. beclomethasone MDI
    (this multiple choice question has been scrambled)

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