Card Set Information
SFOS Blood Innate Host Defense Systems
Examples of Innate barrier defenses
Low pH of sweat, vagina
1. Which leukocytes mature in the bone marrow?
2. Which leukocytes mature in the lymph tissue?
1. Granulocytes, monocytes, some lymphocytes
2. Most lymphocytes/plasma cells
What are the types of leukocytes and their normal %?
Neutrophils - 62%
Lymphocytes - 30%
Monocytes - 5.3%
Eosinophils - 2.3%
Basophils - 0.4%
What is diapedesis?
Process by which neutrophils and monocytes exit pores of blood capillaries to enter tissue spaces
What is opsonization?
Process by which phagocytic cells select targets: antibody binds to target, C3 molecules, which bind to receptors on phagocytic membrane
What is the fate of a phagocytic vesicle?
Fuses with lysosomes and other granules in the neutrophil, making it a digestive vesicle
Specific tissue macrophages and their locations
Histiocytes - skin and subcutaneous tissue
Kupffer Cells - Liver sinusoids
Alveolar macrophages - Lungs
What are the characteristics of inflammation?
Increased capillary permeability
Clotting of interstitial fluid (often)
Granulocyte, monocyte invasion
What causes invasion of neutrophils into an inflamed area?
Inflammatory cytokines (TNF, IL-1) produced by macrophages
What are the main roles of Eosinophils?
Defense against parasites, helminthes (worms)
Phagocytizing allergenic products
What is the main role of Basophils?
Combat certain parasitic and viral infections
Allergic reaction - Immunoglobulin E (IgE) produced attach to Basophils, causing release of histamine...
1. What is leukopenia?
2. What is leukemia?
1. Condition in which the bone marrow produces very few white blood cells
2. Uncontrolled production of white blood cells (often undifferentiated)
Describe the Acute Phase Response?
Leukocytes secrete cytokines in response to bacteria
Cytokines stimulate hepatic synthesis of complement components, fibrinogen, etc.
What produced Platelets? Where?
Megakaryocytes in bone marrow
1. Which cells are granulocytes?
2. Which granules do they contain
1. Neutrophils, Eosinophils, Basophils
2. Nonspecific (azurophilic - lysosomes) and specific granules
1. Which cells are agranulocytes?
2. Which granules do they contain?
1. Monocytes, Lymphocytes
2. Nonspecific (azurophilic) granules ONLY
What are myeloid cells?
Granulocytes and monocytes/macrophages
What are the major functions of Monocytes?
Processing/disposal of necrotic cells
Phagocytosis of foreign bodies
Initiation of immune response, presentation of antigens
What are the options for proteins defining forming vesicles in pinocytosis?
What is leukotriene B4?
A chemo-attractant for neutrophils, released by neutrophils