naloxone.txt

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Author:
papeirce
ID:
77009
Filename:
naloxone.txt
Updated:
2011-04-03 15:32:39
Tags:
paramedic medications drugs prehospital naloxone narcan
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Description:
Prehospital Medication Flashcards for Paramedic School - Massachusetts and Rhode Island
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  1. Naloxone

    Trade Name
    Narcan
  2. Naloxone

    Class
    Narcotic antagonist
  3. Naloxone

    Mechanism of Action
    • Competitive inhibition at narcotic receptor sites
    • Reverse respiratory depression secondary to depressant drugs
    • Completely inhibits the effect of morphine
  4. Naloxone

    Indications
    • Opiate overdose
    • Coma
    • Complete or partial reversal of CNS and respiratory depression induced by opioids
    • Narcotic agonist
    • Morphine, heroin, hydromorphone (Dilaudid), methadone, Meperidine (Demerol), Paregoric, Fentanyl (Sublimase) Oxycodone (Percodan), codeine, propoxyphene (Darvon)
    • Narcotic agonist and antagonist
    • Butorphanol (Stadol)Pentazocine (Talwin)Nalbuphine (Nubain)
    • Decreased level of consciousness
    • Coma of unknown origin
  5. Naloxone

    Contraindications
    • Use with caution in narcotic-dependent patients
    • Use with caution in neonates of narcotic-addicted mothers
  6. Naloxone

    Adverse Reactions
    • Withdrawal symptoms in the addicted patient
    • Tachycardia
    • Hypertension
    • Dysrhythmias
    • Nausea
    • Vomiting
    • Diaphoresis
  7. Naloxone

    Drug Interactions
    Incompatible with bisulfite and alkaline solutions
  8. Naloxone

    How Supplied
    • 0.02 mg/ml (neonate), 0.4 mg/ml, 1 mg/ml, 2.0 mg/5 ml ampules
    • 2 mg/5 ml prefilled syringe
  9. Naloxone

    Dosage and Administration
    Adult
    • 0.4 -2.0 mg IV, IM, SC, IN;
    • min. recommended = 2.0 mg.; repeat at 5 minute
    • intervals to 10 mg maximum dose. (Medical Control may request higher amounts)
  10. Naloxone

    Dosage and Administration
    Pediatric
    0.1 mg/kg dose IV, IM, SC, IN maximum of 0.8 mg; if no response in 10 minutes, administer an additional 0.1 mg/kg dose
  11. Naloxone

    Duration of Action
    • Onset: within 2 minutes
    • Peak effect: variable
    • Duration: 30-60 minutes
  12. Naloxone

    Special Considerations
    • Pregnancy safety: category B
    • Seizures without causal relationship have been reported
    • May not reverse hypotension
    • Use caution when administering to narcotic addicts (violent behavior, etc.)

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