-Slows rate of impulse conduction in atria and ventricles. Depresses myocardial contractility, excitability and prolonging the refractory period. Widens QRS >25%. Can be given IV, IM, or PO for Vent tachycardia & Vent Fibrillation.
Adverse effects: Severe immunologic reactions-lupus, neutropenia, cardiotoxicity, GI symptoms, hypotension
-Increases electrical threshold of ventricle during diastole, suppresses automaticity in the Bundle of His Purkinje system. Used for Ventricular arrhythmias. Bolus first, then infusion. Monitor for: prolonged PR interval and widened QRS.